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Title: The effects of saline or albumin resuscitation on acid-base status and serum electrolytes.
Austin Authors: Bellomo, Rinaldo ;Morimatsu, Hiroshi;French, Craig J;Cole, Louise;Story, David A ;Uchino, Shigehiko;Naka, Toshio
Institutional Author: SAFE Study Investigators
Affiliation: Department of Intensive Care, Austin Hospital, Melbourne, Australia
Issue Date: 1-Dec-2006
Publication information: Critical Care Medicine; 34(12): 2891-7
Abstract: To test whether fluid resuscitation with normal saline or 4% albumin is associated with differential changes in acid-base status and serum electrolytes.Nested cohort study.Three general intensive care units.Six hundred and ninety-one critically ill patients.Randomization of patients to receive blinded solutions of either 4% human albumin or normal saline for fluid resuscitation.Albumin was given to 339 patients and saline to 352. At baseline, both groups had a similar serum bicarbonate, albumin, and base excess levels. After randomization, bicarbonate and base excess increased significantly and similarly over time (p < .0001). On multivariate analysis, fluid resuscitation with albumin predicted a smaller increase in pH (p = .0051), bicarbonate (p = .034), and base excess (p = .015). The amount of fluid was an independent predictor of pH (p < .0001), serum chloride (p < .0001), calcium (p = .0001), bicarbonate (p = .0002), and base excess (p < .0001) on the first day of treatment. In patients who received >3 L of fluids in the first 24 hrs, albumin administration was associated with a significantly greater increase in serum chloride (p = .0026). Acute Physiology and Chronic Health Evaluation II score and the presence of sepsis also independently predicted changes in several electrolytes and acid-base variables.When comparing albumin and saline, the choice and amount of resuscitation fluid are independent predictors of acid-base status and serum electrolytes. When large volumes are given, albumin administration leads to a higher chloride concentration. However, overall differences between the types of fluid are minor, whereas the volume of fluid administered is a much stronger predictor of such changes, which are also influenced by illness severity and the passage of time.
Gov't Doc #: 16971855
DOI: 10.1097/01.CCM.0000242159.32764.86
Type: Journal Article
Subjects: Acid-Base Equilibrium.drug effects
Albumins.administration & dosage.therapeutic use
Blood Chemical Analysis
Critical Illness
Double-Blind Method
Fluid Therapy.methods
Intensive Care Units
Middle Aged
Prospective Studies
Sodium Chloride.administration & dosage.therapeutic use
Appears in Collections:Journal articles

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