Good clinical outcomes but high rates of adverse reactions during linezolid therapy for serious infections: a proposed protocol for monitoring therapy in complex patients.

Bishop, Emma; Melvani, Sharmila; Howden, Benjamin P; Charles, Patrick G P; Grayson, M Lindsay

doi:10.1128/AAC.50.4.1599-1602.2006

Title

Good clinical outcomes but high rates of adverse reactions during linezolid therapy for serious infections: a proposed protocol for monitoring therapy in complex patients.

Publication Date

2006-04-01

Author(s)

Bishop, Emma

Melvani, Sharmila

Howden, Benjamin P

Charles, Patrick G P

Grayson, M Lindsay

Type of document

Journal Article

OrcId

#PLACEHOLDER_PARENT_METADATA_VALUE#

DOI

10.1128/AAC.50.4.1599-1602.2006

Abstract

We assessed the toxicity and clinical outcomes associated with linezolid therapy (mean duration, 29+/-28 days; range, 8 to 185 days) in 44 patients with serious gram-positive infections. Although a clinical cure was achieved in 73% of the cases, 28/44 (64%) had adverse reactions (thrombocytopenia, n=13; anemia, n=7; gastrointestinal, n=12; peripheral neuropathy, n=1; serotonin syndrome, n=1), such that a systematic monitoring protocol was developed.

Link

link

Citation

Antimicrobial Agents and Chemotherapy; 50(4): 1599-602

Jornal Title

Antimicrobial Agents and Chemotherapy

Austin Health

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