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Title: Good clinical outcomes but high rates of adverse reactions during linezolid therapy for serious infections: a proposed protocol for monitoring therapy in complex patients.
Austin Authors: Bishop, Emma;Melvani, Sharmila;Howden, Benjamin P ;Charles, Patrick G P ;Grayson, M Lindsay 
Affiliation: Infectious Diseases Department, Austin Health, Studley Rd., Heidelberg, Victoria 3084, Australia
Issue Date: 1-Apr-2006
Publication information: Antimicrobial Agents and Chemotherapy; 50(4): 1599-602
Abstract: We assessed the toxicity and clinical outcomes associated with linezolid therapy (mean duration, 29+/-28 days; range, 8 to 185 days) in 44 patients with serious gram-positive infections. Although a clinical cure was achieved in 73% of the cases, 28/44 (64%) had adverse reactions (thrombocytopenia, n=13; anemia, n=7; gastrointestinal, n=12; peripheral neuropathy, n=1; serotonin syndrome, n=1), such that a systematic monitoring protocol was developed.
Gov't Doc #: 16569895
DOI: 10.1128/AAC.50.4.1599-1602.2006
Type: Journal Article
Subjects: Acetamides.adverse effects
Aged, 80 and over
Anti-Infective Agents.adverse effects
Gram-Positive Bacterial Infections.drug therapy
Middle Aged
Oxazolidinones.adverse effects
Retrospective Studies
Appears in Collections:Journal articles

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