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Title: An unusual case of tumor-to-cavernoma metastasis. A case report and literature review.
Austin Authors: Chan, Chow Huat Patrick;Fabinyi, Gavin C ;Kalnins, Renate M
Affiliation: Department of Neurosurgery, University of Melbourne, Austin Health, Heidelberg 3084, Victoria, Australia
Issue Date: 1-Apr-2006
Publication information: Surgical Neurology; 65(4): 402-8, discussion 409
Abstract: Metastases of systemic neoplasia to preexisting intracranial mass lesions are uncommon phenomena. Tumor-to-intracranial cavernoma metastases are even more unusual and rarely reported. We describe here a case of melanoma to intracranial cavernoma metastasis.A 39-year-old woman presented after an episode of generalized tonic-clonic seizure on a background of infrequent epilepsy. She was found to have a left parieto-occipital hemorrhagic lesion on imaging studies. The lesion was surgically removed and histopathology showed a metastatic melanoma within a cavernoma.This case report represents the third recorded case of tumor-to-intracranial cavernoma metastasis and the first melanoma to intracranial cavernoma metastasis. An extensive literature review of tumor-to-intracranial tumor metastases was conducted and disclosed an increase in reporting of the uncommon phenomenon of metastasis into preexisting intracranial lesions. It should therefore be considered as a differential diagnosis in patients with history of systemic cancer who present with progression of preexistent intracranial lesions.
DOI: 10.1016/j.surneu.2005.06.028
Type: Journal Article
Subjects: Adult
Brain Neoplasms.pathology.secondary
Hemangioma, Cavernous, Central Nervous System.pathology
Magnetic Resonance Imaging
Neoplasm Metastasis.pathology
Neurosurgical Procedures
Tomography, X-Ray Computed
Treatment Outcome
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