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Title: Angiotensin-converting enzyme in macro- and microvessels of the rat.
Austin Authors: Jandeleit, K;Jackson, B ;Perich, R;Paxton, D;Johnston, Colin I
Affiliation: University of Melbourne, Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia
Issue Date: 1-May-1991
Publication information: Clinical and Experimental Pharmacology & Physiology; 18(5): 353-6
Abstract: 1. Angiotensin-converting enzyme (ACE) was measured in the aorta, cerebral and mesenteric microvessels of Wistar-Kyoto rats using a specific radioligand assay. 2. Ligand binding studies revealed a four-fold increase in concentration of ACE in mesenteric microvessels, compared with aorta or brain microvessels. The dissociation constant (Kd) was similar in all tissues. 3. The effects of oral administration of the ACE inhibitor S9650 on vascular ACE in vivo were measured. 4. S9650 produced a dose-dependent inhibition of vascular ACE from brain and mesenteric microvessels.
Gov't Doc #: 1648462
Type: Journal Article
Subjects: Angiotensin-Converting Enzyme Inhibitors.pharmacology
Bicyclo Compounds.pharmacology
Bicyclo Compounds, Heterocyclic
Binding Sites
Blood Vessels.enzymology
Peptidyl-Dipeptidase A.metabolism
Radioligand Assay
Rats, Inbred WKY
Appears in Collections:Journal articles

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