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Title: Treatment with supplementary arginine, vitamin C and zinc in patients with pressure ulcers: a randomised controlled trial.
Austin Authors: Desneves, Katherine J ;Todorovic, Bree E;Cassar, Ann;Crowe, Timothy C
Affiliation: Department of Nutrition and Dietetics, Austin Health, Studley Road, Heidelberg 3084, and School of Exercise and Nutrition Sciences, Deakin University, Burwood, Australia
Issue Date: 15-Nov-2005
Publication information: Clinical Nutrition (edinburgh, Scotland) 2005; 24(6): 979-87
Abstract: Nutrients putatively implicated in pressure ulcer healing were evaluated in a clinical setting.Sixteen inpatients with a stage 2, 3 or 4 pressure ulcer randomised to receive daily a standard hospital diet; a standard diet plus two high-protein/energy supplements; or a standard diet plus two high-protein/energy supplements containing additional arginine (9 g), vitamin C (500 mg) and zinc (30 mg). Nutritional status measurements (dietary, anthropometric and biochemical) and pressure ulcer size and severity (by PUSH tool; Pressure Ulcer Scale for Healing; 0=completely healed, 17=greatest severity) were measured weekly for 3 weeks.Patients' age and BMI ranges were 37-92 years and 16.4-28.1 k g/m2) respectively. Baseline PUSH scores were similar between groups (8.7+/-0.5). Only patients receiving additional arginine, vitamin C and zinc demonstrated a clinically significant improvement in pressure ulcer healing (9.4+/-1.2 vs. 2.6+/-0.6; baseline and week 3, respectively; P<0.01). All patient groups presented with low serum albumin and zinc and elevated C-reactive protein. There were no significant changes in biochemical markers, oral dietary intake or weight in any group.In this small set of patients, supplementary arginine, vitamin C and zinc significantly improved the rate of pressure ulcer healing. The results need to be confirmed in a larger study.
Gov't Doc #: 16297506
DOI: 10.1016/j.clnu.2005.06.011
Journal: Clinical nutrition (Edinburgh, Scotland)
Type: Journal Article
Subjects: Adult
Aged, 80 and over
Antioxidants.therapeutic use
Arginine.therapeutic use
Ascorbic Acid.therapeutic use
Blood Chemical Analysis
Dietary Supplements
Middle Aged
Nutritional Status
Pressure Ulcer.drug therapy
Severity of Illness Index
Trace Elements.therapeutic use
Treatment Outcome
Wound Healing.drug effects
Zinc.therapeutic use
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