Please use this identifier to cite or link to this item:
Title: Renal hyperfiltration in type 2 diabetes: effect of age-related decline in glomerular filtration rate.
Austin Authors: Premaratne, Erosha ;Macisaac, Richard J;Tsalamandris, Con;Panagiotopoulos, Sianna ;Smith, T;Jerums, George 
Affiliation: Endocrinology Unit, Department of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia
Issue Date: 1-Nov-2005
Publication information: Diabetologia 2005; 48(12): 2486-93
Abstract: We sought to characterise the effect of the age-related decline of GFR on hyperfiltration in type 2 diabetes and to identify clinical characteristics associated with hyperfiltration.GFR was measured in 662 type 2 diabetic patients by plasma disappearance of 99 m-technetium-diethylene-triamine-penta-acetic acid. The prevalence of hyperfiltration was calculated using both an age-unadjusted GFR threshold of >130 ml min(-1) 1.73 m(-2) and an age-adjusted threshold incorporating a decline of 1 ml min(-1) year(-1) after the age of 40. The hyperfiltering patients were compared with type 2 diabetic subjects who had a GFR between 90 and 130 ml min(-1) 1.73 m(-2) and were matched for age, sex and disease duration to allow for identification of modifiable factors associated with hyperfiltration.The prevalence of hyperfiltration was 7.4% when age-unadjusted and 16.6% when age-adjusted definitions were used. The age-unadjusted vs -adjusted prevalence rates for hyperfiltration were 50 vs 50%, 12.9 vs 23.4% and 0.3 vs 9.0% for patients aged <40 years, 40 to 65 years and >65 years, respectively. Both the age-unadjusted and -adjusted hyperfiltration groups had lower mean diastolic blood pressure and lower serum creatinine levels than the control groups. Although the age-unadjusted hyperfiltration group had larger kidneys compared to the control group, this difference was no longer significant when the age-adjusted definition was used. There were no differences in HbA(1)c, mean arterial pressure, antihypertensive use, insulin therapy, dyslipidaemia, frequency of macro- or microvascular complications, BMI, urinary sodium, urea and albumin excretion between the groups.Hyperfiltration was still more common among younger patients with type 2 diabetes even after adjusting for the expected age-related decline in GFR. Hyperfiltration was associated with a lower mean diastolic blood pressure independent of age.
Gov't Doc #: 16261309
DOI: 10.1007/s00125-005-0002-9
ORCID: 0000-0002-0845-0001
Type: Journal Article
Subjects: Adult
Aged, 80 and over
Blood Pressure.physiology
Cohort Studies
Diabetes Mellitus, Type 2.blood.physiopathology
Diabetic Nephropathies.blood.epidemiology.physiopathology
Glomerular Filtration Rate.physiology
Middle Aged
Appears in Collections:Journal articles

Files in This Item:
File Description SizeFormat 
16261309.pdf205.19 kBAdobe PDFThumbnail
Show full item record

Page view(s)

checked on Dec 7, 2022


checked on Dec 7, 2022

Google ScholarTM


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.