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https://ahro.austin.org.au/austinjspui/handle/1/19576| Title: | Treatable traits can be identified in a severe asthma registry and predict future exacerbations. | Austin Authors: | McDonald, Vanessa M;Hiles, Sarah A;Godbout, Krystelle;Harvey, Erin S;Marks, Guy B;Hew, Mark;Peters, Matthew;Bardin, Philip G;Reynolds, Paul N;Upham, John W;Baraket, Melissa;Bhikoo, Zaheerodin;Bowden, Jeffrey;Brockway, Ben;Chung, Li Ping;Cochrane, Belinda;Foxley, Gloria;Garrett, Jeffrey;Jayaram, Lata;Jenkins, Christine;Katelaris, Constance;Katsoulotos, Gregory;Koh, Mariko S;Kritikos, Vicky;Lambert, Marina;Langton, David;Lara Rivero, Alexis;Middleton, Peter G;Nanguzgambo, Aldoph;Radhakrishna, Naghmeh;Reddel, Helen;Rimmer, Janet;Southcott, Anne Marie;Sutherland, Michael F;Thien, Francis;Wark, Peter A B;Yang, Ian A;Yap, Elaine;Gibson, Peter G | Affiliation: | UQ Thoracic Research Centre, Faculty of Medicine, The University of Queensland, Chermside, QLD, Australia Department of Respiratory Medicine, Eastern Health and Monash University, Box Hill, Victoria, Australia The Prince Charles Hospital, Metro North Hospital and Health Service, Chermside West, QLD, Australia Centre of Excellence in Severe Asthma and Priority Research Centre for Healthy Lungs, Faculty of Health, University of Newcastle, Callaghan, NSW, Australia Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval, Québec, QC, Canada Department of Respiratory and Sleep Medicine, John Hunter Hospital, New Lambton Heights, NSW, Australia South Western Sydney Clinical School, UNSW Sydney, Liverpool, NSW, Australia Woolcock Institute of Medical Research, The University of Sydney, Glebe, NSW, Australia Difficult Asthma Clinic, Allergy, Asthma and Clinical Immunology, Alfred Health, Melbourne, Victoria, Australia Department of Thoracic Medicine, Concord Hospital, Concord, NSW, Australia Lung and Sleep Medicine, Monash University and Medical Centre, Clayton, Victoria, Australia Department of Lung Research, Hanson Institute, Adelaide, SA, Australia Department of Thoracic Medicine, Royal Adelaide Hospital, Adelaide, SA, Australia The University of Queensland Diamantina Institute, Woolloongabba, QLD, Australia Department of Respiratory Medicine, Princess Alexandra Hospital, Woolloongabba, QLD, Australia Department of Respiratory Medicine, Liverpool Hospital and School of Medicine, UNSW Sydney, Liverpool, NSW, Australia Respiratory Department, Waikato Hospital, Hamilton, New Zealand Department of Respiratory, Allergy and Sleep Medicine, Flinders Medical Centre, Bedford Park, SA, Australia Department of Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand Department of Respiratory Medicine, Fiona Stanley Hospital, Murdoch, WA, Australia Department of Respiratory and Sleep Medicine, Campbelltown Hospital, Campbelltown, NSW, Australia School of Medicine, Western Sydney University, Campbelltown, NSW, Australia Respiratory Department, Middlemore Hospital, Auckland, New Zealand Department of Medicine, Melbourne Clinical School, University of Melbourne, Melbourne, Victoria, Australia Department of Respiratory and Sleep Disorders Medicine, Western Health, Footscray, Victoria, Australia Concord Clinical School and Respiratory Discipline, University of Sydney, Concord, NSW, Australia Respiratory Group, The George Institute for Global Health, Newtown, NSW, Australia Respiratory Medicine, UNSW Sydney, Liverpool, NSW, Australia Immunology Department, Campbelltown Hospital, Campbelltown, NSW, Australia St George Specialist Centre, Kogarah, NSW, Australia Department of Respiratory and Critical Care Medicine, Singapore General Hospital, Singapore Duke - National University Singapore Medical School, Singapore Woolcock Institute of Medical Research, Quality Use of Respiratory Medicines, The University of Sydney, Glebe, NSW, Australia Department of Respiratory Medicine, Royal Prince Alfred Hospital, Camperdown, NSW, Australia Respiratory Services, MidCentral Health, Palmerston North Hospital, Palmerston North, New Zealand Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Victoria, Australia Department of Thoracic Medicine, Frankston Hospital, Frankston, Victoria, Australia Sydney Medical School, University of Sydney, Camperdown, NSW, Australia Ludwig Engel Centre for Respiratory Research, Westmead Institute of Medical Research, Westmead, NSW, Australia Department of Respiratory and Sleep Medicine, Westmead Hospital, Westmead, NSW, Australia Thoracic Medicine, St Vincent's Clinic, Darlinghurst, NSW, Australia Department of Respiratory and Sleep Medicine, Austin Health, Heidelberg, Victoria, Australia |
Issue Date: | 2019 | Date: | 2018-09-19 | Publication information: | Respirology (Carlton, Vic.) 2019; 24(1): 37-47 | Abstract: | A new taxonomic and management approach, termed treatable traits, has been proposed for airway diseases including severe asthma. This study examined whether treatable traits could be identified using registry data and whether particular treatable traits were associated with future exacerbation risk. The Australasian Severe Asthma Web-Based Database (SAWD) enrolled 434 participants with severe asthma and a comparison group of 102 participants with non-severe asthma. Published treatable traits were mapped to registry data fields and their prevalence was described. Participants were characterized at baseline and every 6 months for 24 months. In SAWD, 24 treatable traits were identified in three domains: pulmonary, extrapulmonary and behavioural/risk factors. Patients with severe asthma expressed more pulmonary and extrapulmonary treatable traits than non-severe asthma. Allergic sensitization, upper-airway disease, airflow limitation, eosinophilic inflammation and frequent exacerbations were common in severe asthma. Ten traits predicted exacerbation risk; among the strongest were being prone to exacerbations, depression, inhaler device polypharmacy, vocal cord dysfunction and obstructive sleep apnoea. Treatable traits can be assessed using a severe asthma registry. In severe asthma, patients express more treatable traits than non-severe asthma. Traits may be associated with future asthma exacerbation risk demonstrating the clinical utility of assessing treatable traits. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/19576 | DOI: | 10.1111/resp.13389 | Journal: | Respirology | PubMed URL: | 30230137 | Type: | Journal Article | Subjects: | co-morbidity exacerbation registry severe asthma treatable traits |
| Appears in Collections: | Journal articles |
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