Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/19012
Title: Changing epidemiology of candidaemia in Australia.
Authors: Chapman, Belinda;Slavin, Monica;Marriott, Debbie;Halliday, Catriona;Kidd, Sarah;Arthur, Ian;Bak, Narin;Heath, Christopher H;Kennedy, Karina;Morrissey, C Orla;Sorrell, Tania C;van Hal, Sebastian;Keighley, Caitlin;Goeman, Emma;Underwood, Neil;Hajkowicz, Krispin;Hofmeyr, Ann;Leung, Michael;Macesic, Nenad;Botes, Jeannie;Blyth, Christopher;Cooley, Louise;George, C Robert;Kalukottege, Pankaja;Kesson, Alison;McMullan, Brendan;Baird, Robert;Robson, Jennifer;Korman, Tony M;Pendle, Stella;Weeks, Kerry;Liu, Eunice;Cheong, Elaine;Chen, Sharon
Affiliation: Department of Microbiology and Infectious Diseases, Concord Hospital, Sydney, NSW, Australia
Department of Microbiology, Australian Clinical Laboratories, Sydney, NSW, Australia
Department of Microbiology, Pathology North, Royal North Shore Hospital, Sydney, NSW, Australia
Westmead Institute for Medical Research, The University of Sydney, Sydney, NSW, Australia
Department of Infectious Diseases, Peter MacCallum Cancer Centre, Victorian Infectious Diseases Service at the Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia
Centre for Infectious Diseases and Microbiology Laboratory Services, ICPMR, Westmead Hospital, Westmead, Sydney, NSW, Australia
National Mycology Reference Centre, SA Pathology, Adelaide, SA, Australia
Department of Infectious Diseases, Royal Adelaide Hospital, Adelaide, SA, Australia
Department of Microbiology and Infectious Diseases, Royal Perth Hospital, Department of Microbiology, PathWest Laboratory Medicine Fiona Stanley Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, WA, Australia
Department of Infectious Diseases and Microbiology, Canberra Hospital, Australian National University Medical School, Canberra, ACT, Australia
Department of Infectious Diseases, Alfred Health and Monash University, Melbourne, VIC, Australia
Centre for Infectious Diseases and Microbiology Westmead Institute for Medical Research, Westmead Hospital and the Marie Bashir Institute for Infectious Diseases and Biosecurity, University of Sydney, Sydney, NSW, Australia
Department of Infectious Diseases and Microbiology, Royal Prince Alfred Hospital, Sydney, NSW, Australia
Department of Microbiology and Infectious Diseases, St Vincent's Hospital, Sydney, NSW, Australia
Infection Management Services, Princess Alexandra Hospital, Brisbane, Queensland, Australia
Department of Infectious Diseases, Royal Brisbane and Women's Hospital, School of Medicine, University of Queensland, Brisbane, Queensland, Australia
Department of Microbiology and Infectious Diseases, Liverpool Hospital, Sydney, NSW, Australia
Department of Microbiology, PathWest Laboratory Medicine, QEII Medical Centre, Nedlands, WA, Australia
Department of Infectious Diseases, Austin Health, Heidelberg, Victoria, Australia
Division of Infectious Diseases, Columbia University Medical Center, New York City, NY, USA
Department of Microbiology, SEALS South Pathology, Wollongong Hospital, Wollongong, NSW, Australia
School of Paediatrics and Child Health, University of Western Australia, Subiaco, WA, Australia and Department of Infectious Diseases, Princess Margaret Hospital, Subiaco, WA, Australia
Department of Microbiology and Infectious Diseases, Royal Hobart Hospital, Hobart, Tasmania, Australia
Department of Microbiology, South Eastern Area Laboratory Services, Prince of Wales Hospital, Sydney, NSW, Australia
Department of Microbiology, Pathology -North, Hunter, Newcastle, NSW, Australia
Department of Infectious Diseases and Microbiology, The Children's Hospital, Westmead and Discipline of Paediatrics and Child Health, University of Sydney, Sydney, NSW, Australia
Department of Immunology and Infectious Diseases, Sydney Children's Hospital, Randwick, NSW, Australia
Department of Microbiology, Royal Darwin Hospital, Darwin, NT, Australia
Sullivan and Nicolaides Pathology, Brisbane, Queensland, Australia
Monash Infectious Diseases, Monash University and Monash Health, Melbourne, VIC, Australia
Issue Date: 1-Apr-2017
Citation: The Journal of antimicrobial chemotherapy 2017; 72(4): 1103-1108
Abstract: Knowledge of contemporary epidemiology of candidaemia is essential. We aimed to identify changes since 2004 in incidence, species epidemiology and antifungal susceptibilities of Candida spp. causing candidaemia in Australia. These data were collected from nationwide active laboratory-based surveillance for candidaemia over 1 year (within 2014-2015). Isolate identification was by MALDI-TOF MS supplemented by DNA sequencing. Antifungal susceptibility testing was performed using Sensititre YeastOne™. A total of 527 candidaemia episodes (yielding 548 isolates) were evaluable. The mean annual incidence was 2.41/105 population. The median patient age was 63 years (56% of cases occurred in males). Of 498 isolates with confirmed species identity, Candida albicans was the most common (44.4%) followed by Candida glabrata complex (26.7%) and Candida parapsilosis complex (16.5%). Uncommon Candida species comprised 25 (5%) isolates. Overall, C. albicans (>99%) and C. parapsilosis (98.8%) were fluconazole susceptible. However, 16.7% (4 of 24) of Candida tropicalis were fluconazole- and voriconazole-resistant and were non-WT to posaconazole. Of C. glabrata isolates, 6.8% were resistant/non-WT to azoles; only one isolate was classed as resistant to caspofungin (MIC of 0.5 mg/L) by CLSI criteria, but was micafungin and anidulafungin susceptible. There was no azole/echinocandin co-resistance. We report an almost 1.7-fold proportional increase in C. glabrata candidaemia (26.7% versus 16% in 2004) in Australia. Antifungal resistance was generally uncommon, but azole resistance (16.7% of isolates) amongst C. tropicalis may be emerging.
URI: http://ahro.austin.org.au/austinjspui/handle/1/19012
DOI: 10.1093/jac/dkw422
PubMed URL: 28364558
Type: Journal Article
Research Support, Non-U.S. Gov't
Appears in Collections:Journal articles

Files in This Item:
There are no files associated with this item.


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.