Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/17648
Title: EphA3 as a target for antibody immunotherapy in acute lymphoblastic leukemia.
Authors: Charmsaz, S;Al-Ejeh, F;Yeadon, T M;Miller, K J;Smith, F M;Stringer, B W;Moore, A S;Lee, Fook-Thean;Cooper, L T;Stylianou, C;Yarranton, G T;Woronicz, J;Scott, A M;Lackmann, M;Boyd, A W
Affiliation: Leukaemia Foundation of Queensland Laboratory, QIMR-Berghofer Medical Research Institute, Brisbane, QLD, Australia
Department of Medicine, University of Queensland, Brisbane, QLD, Australia
Department of Surgery, Royal College of Surgeons, Dublin, Ireland, UK
Personalised Medicine Team, QIMR-Berghofer Medical Research Institute, Brisbane, QLD, Australia
University of Queensland Diamantina Institute and UQ Child Health Research Centre, The University of Queensland, Brisbane, Australia
Oncology Service Children's Health Queensland Hospital and Health Service, Brisbane, QLD, Australia
Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia
School of Cancer Medicine, La Trobe University, Melbourne, VIC, Australia
KaloBios Pharmaceuticals Inc., Brisbane, CA, USA
Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC, Australia
Issue Date: Aug-2017
EDate: 2016-12-06
Citation: Leukemia 2017; 31(8): 1779-1787
Abstract: The human EphA3 gene was discovered in a pre-B acute lymphoblastic leukemia (pre-B-ALL) using the EphA3-specific monoclonal antibody (mAb), IIIA4, which binds and activates both human and mouse EphA3. We use two models of human pre-B-ALL to examine EphA3 function, demonstrating effects on pre-B-cell receptor signaling. In therapeutic targeting studies, we demonstrated antitumor effects of the IIIA4 mAb in EphA3-expressing leukemic xenografts and no antitumor effect in the xenografts with no EphA3 expression providing evidence that EphA3 is a functional therapeutic target in pre-B-ALL. Here we show that the therapeutic effect of the anti-EphA3 antibody was greatly enhanced by adding an α-particle-emitting 213Bismuth payload.
URI: http://ahro.austin.org.au/austinjspui/handle/1/17648
DOI: 10.1038/leu.2016.371
PubMed URL: 27922598
Type: Journal Article
Appears in Collections:Journal articles

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