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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jenkins, T A | en |
dc.contributor.author | Chai, Syn Y | en |
dc.contributor.author | Mendelsohn, Frederick AO | en |
dc.date.accessioned | 2015-05-16T03:24:43Z | |
dc.date.available | 2015-05-16T03:24:43Z | |
dc.date.issued | 1997-07-08 | en |
dc.identifier.citation | Clinical and Experimental Hypertension (new York, N.y. : 1993); 19(5-6): 645-58 | en |
dc.identifier.govdoc | 9247745 | en |
dc.identifier.other | PUBMED | en |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/13537 | en |
dc.description.abstract | We have previously demonstrated that angiotensin II stimulates the release of dopamine from the normotensive rat striatum via the AT1 receptor. In this study, the effect of angiotensin II-stimulated striatal dopamine release in the spontaneous hypertensive rat was compared to normotensive controls. In the spontaneous hypertensive rat, angiotensin II stimulated dopamine release to 169 +/- 13% (P < 0.05) in the experimental period, with levels remaining high in the recovery phase, 158 +/- 16% (P < 0.05). This effect was not significantly different from the response in normotensive controls, in which angiotensin II stimulated dopamine release to 149 +/- 18% (P < 0.05) in the experimental period, with the effect also persisting through the recovery period, 244 +/- 62% (P < 0.05). Thus, despite reports of increased activity of the brain angiotensin II and dopamine systems in the spontaneous hypertensive rat, there is no evidence of abnormal regulation of the striatonigral dopamine system. | en |
dc.language.iso | en | en |
dc.subject.other | Angiotensin II.pharmacology | en |
dc.subject.other | Animals | en |
dc.subject.other | Corpus Striatum.drug effects.secretion | en |
dc.subject.other | Dopamine.secretion | en |
dc.subject.other | Hypertension.physiopathology | en |
dc.subject.other | Microdialysis | en |
dc.subject.other | Rats | en |
dc.subject.other | Rats, Inbred SHR | en |
dc.subject.other | Rats, Sprague-Dawley | en |
dc.subject.other | Species Specificity | en |
dc.title | Effect of angiotensin II on striatal dopamine release in the spontaneous hypertensive rat. | en |
dc.type | Journal Article | en |
dc.identifier.journaltitle | Clinical and experimental hypertension (New York, N.Y. : 1993) | en |
dc.identifier.affiliation | University of Melbourne, Department of Medicine, Austin and Repatriation Medical Centre, Heidelberg, Victoria, Australia | en |
dc.description.pages | 645-58 | en |
dc.relation.url | https://pubmed.ncbi.nlm.nih.gov/9247745 | en |
dc.type.austin | Journal Article | en |
item.languageiso639-1 | en | - |
item.openairetype | Journal Article | - |
item.cerifentitytype | Publications | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | none | - |
Appears in Collections: | Journal articles |
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