Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/12191
Title: Community-associated methicillin-resistant Staphylococcus aureus transmission in households of infected cases: a pooled analysis of primary data from three studies across international settings.
Authors: Knox, J;Van Rijen, M;Uhlemann, A-C;Miller, M;Hafer, C;Vavagiakis, P;Shi, Q;Johnson, Paul D R;Coombs, Geoffrey W;Kluytmans-Van Den Bergh, M;Kluytmans, J;Bennett, Catherine M;Lowy, F D
Affiliation: Division of Infectious Diseases, Department of Medicine,Columbia University,College of Physicians & Surgeons, New York,USA.
Department of Epidemiology, Mailman School of Public Health,Columbia University;New York,USA.
Panna Technologies,New York,USA.
Department of Epidemiology and Community Health, School of Health Sciences and Practice,New York Medical College,Valhalla,USA.
Austin Health,Melbourne, Victoria,Australia.
Australian Collaborating Centre for Enterococcus and Staphylococcus Species (ACCESS) Typing and Research, School of Biomedical Sciences,Curtin University,Perth, Western Australia,Australia.
Amphia Hospital,Breda,The Netherlands.
Deakin University,Melbourne, Victoria,Australia.
Issue Date: 24-Apr-2014
Citation: Epidemiology and Infection 2014; 143(2): 354-65
Abstract: Diverse strain types of methicillin-resistant Staphylococcus aureus (MRSA) cause infections in community settings worldwide. To examine heterogeneity of spread within households and to identify common risk factors for household transmission across settings, primary data from studies conducted in New York (USA), Breda (The Netherlands), and Melbourne (Australia) were pooled. Following MRSA infection of the index patient, household members completed questionnaires and provided nasal swabs. Swabs positive for S. aureus were genotyped by spa sequencing. Poisson regression with robust error variance was used to estimate prevalence odds ratios for transmission of the clinical isolate to non-index household members. Great diversity of strain types existed across studies. Despite differences between studies, the index patient being colonized with the clinical isolate at the home visit (P < 0·01) and the percent of household members aged <18 years (P < 0·01) were independently associated with transmission. Targeted decolonization strategies could be used across geographical settings to limit household MRSA transmission.
Internal ID Number: 24763185
URI: http://ahro.austin.org.au/austinjspui/handle/1/12191
DOI: 10.1017/S0950268814000983
URL: http://www.ncbi.nlm.nih.gov/pubmed/24763185
Type: Journal Article
Subjects: Adolescent
Adult
Australia.epidemiology
Child
Child, Preschool
Community-Acquired Infections.epidemiology.microbiology.transmission
Family Characteristics
Female
Humans
Infant
Male
Methicillin-Resistant Staphylococcus aureus
Netherlands.epidemiology
New York.epidemiology
Retrospective Studies
Staphylococcal Infections.epidemiology.microbiology.transmission
Young Adult
Appears in Collections:Journal articles

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