Please use this identifier to cite or link to this item:
https://ahro.austin.org.au/austinjspui/handle/1/11410
Title: | Skeletal and hormonal responses to vitamin D supplementation during sunlight deprivation in Antarctic expeditioners. | Austin Authors: | Iuliano-Burns, Sandra ;Ayton, J;Hillam, S;Jones, G;King, K;Macleod, S;Seeman, Ego | Affiliation: | Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia | Issue Date: | 4-Jan-2012 | Publication information: | Osteoporosis International : A Journal Established As Result of Cooperation Between the European Foundation For Osteoporosis and the National Osteoporosis Foundation of The Usa 2012; 23(10): 2461-7 | Abstract: | Sunlight deprivation results in vitamin D deficiency but serum vitamin D levels can be maintained above 50 nmol/L when supplemented with 50,000 IU at least every alternate month.Antarctic expeditioners are exposed to prolonged sunlight deprivation resulting in vitamin D deficiency. We hypothesised that monthly dosing of 50,000 IU vitamin D (~1,600 IU daily) will increase serum 25-hydroxyvitamin D (25(OH)D), suppress parathyroid hormone (PTH) and improve bone mineral density (BMD), 50,000 IU alternate months (~800 IU daily) will maintain these measures, while a single 50,000 IU dose pre-departure (~1,00 IU daily) will not be protective.This was a randomised double-blind study involving 110 healthy adults: 91 males, mean age 41 years (range 24-65 years) working in Antarctica for up to 12 months, who we administered 50,000 IU vitamin D3 monthly, alternate months or a single dose pre-departure. Serum 25(OH)D, PTH, osteocalcin, CTx and calcium were assessed at baseline, mid- and end of expedition. Proximal femur and lumbar spine BMD were assessed pre- and post-expedition.Baseline 25(OH)D was 59 ± 14 nmol/L. By mid-expedition, 25(OH)D increased by 7 nmol/L in those supplemented monthly (p < 0.05) and remained unchanged in those supplemented in alternate months. In those given a single dose pre-departure, 25(OH)D decreased by 8 nmol/L (p < 0.05) and PTH increased by 27% (p < 0.09). Serum osteocalcin increased by ~22% in all groups but BMD remained unchanged. If serum 25(OH)D was >50 nmol/L at baseline, 25(OH)D was maintained above this level with all regimens. If 25(OH)D was <50 nmol/L at baseline, monthly or alternate month regimens were needed to achieve levels >50 nmol/L, the single pre-departure dose was ineffective.During sunlight deprivation of up to 12 months, serum 25(OH)D levels can be maintained above 50 nmol/L when expeditioners are provided with 50,000 I U at least every alternate month. | Gov't Doc #: | 22215183 | URI: | https://ahro.austin.org.au/austinjspui/handle/1/11410 | DOI: | 10.1007/s00198-011-1858-9 | Journal: | Osteoporosis International | URL: | https://pubmed.ncbi.nlm.nih.gov/22215183 | Type: | Journal Article | Subjects: | Adult Aged Antarctic Regions Calcium.blood Dietary Supplements Double-Blind Method Drug Administration Schedule Expeditions Female Femur.physiopathology Humans Lumbar Vertebrae.physiopathology Male Middle Aged Osteocalcin.blood Parathyroid Hormone.blood Sunlight Vitamin D.administration & dosage.analogs & derivatives.blood.therapeutic use Vitamin D Deficiency.complications.physiopathology.prevention & control Young Adult |
Appears in Collections: | Journal articles |
Files in This Item:
File | Size | Format | |
---|---|---|---|
22215183.pdf | 54.43 kB | Adobe PDF | View/Open |
Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.