1. AHRO : Austin Health Research Online
  2. Austin Health research
  3. Journal articles
Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10256
Full metadata record
DC FieldValueLanguage
dc.contributor.authorSmith, Kelly Aen
dc.contributor.authorKovac, Suzanaen
dc.contributor.authorAnderson, Gregory Jen
dc.contributor.authorShulkes, Arthuren
dc.contributor.authorBaldwin, Graham Sen
dc.date.accessioned2015-05-15T23:38:52Z
dc.date.available2015-05-15T23:38:52Z
dc.date.issued2006-10-18en
dc.identifier.citationFebs Letters 2006; 580(26): 6195-8en
dc.identifier.govdoc17064691en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/10256en
dc.description.abstractGastric acid production is important in intestinal iron absorption. The peptide hormone gastrin exists in both amidated and non-amidated forms, which stimulate and potentiate gastric acid secretion, respectively. Since non-amidated gastrins require ferric ions for biological activity in vitro, this study investigated the connection between iron status and gastrin by measurement of circulating gastrin concentrations in mice and humans with hemochromatosis. Gastrin concentrations are increased in the plasma and gastric mucosa of Hfe(-/-) mice, and in the sera of humans with HFE-related hemochromatosis. The discovery of a relationship between iron status and circulating gastrin concentrations opens a new perspective on the mechanisms of iron homeostasis.en
dc.language.isoenen
dc.subject.otherAnimalsen
dc.subject.otherGastric Mucosa.chemistryen
dc.subject.otherGastrins.analysis.blood.isolation & purificationen
dc.subject.otherGlycineen
dc.subject.otherHemochromatosis.blood.metabolismen
dc.subject.otherHistocompatibility Antigens Class I.geneticsen
dc.subject.otherHumansen
dc.subject.otherIron.blood.physiologyen
dc.subject.otherMembrane Proteins.deficiency.geneticsen
dc.subject.otherMiceen
dc.subject.otherMice, Knockouten
dc.titleCirculating gastrin is increased in hemochromatosis.en
dc.typeJournal Articleen
dc.identifier.journaltitleFEBS lettersen
dc.identifier.affiliationUniversity of Melbourne Department of Surgery, Austin Health, Level 8, Lance Townsend Building, Studley Road, Heidelberg, Vic. 3084, Australiaen
dc.identifier.doi10.1016/j.febslet.2006.10.021en
dc.description.pages6195-8en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/17064691en
dc.type.austinJournal Articleen
item.languageiso639-1en-
item.openairetypeJournal Article-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
Appears in Collections:Journal articles
Show simple item record

Page view(s)

12
checked on May 12, 2024

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.