Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/10013
Title: Rare genetically defined causes of dementia.
Authors: Novakovic, K E;Villemagne, Victor L;Rowe, Christopher C;Masters, Colin L
Affiliation: Department of Nuclear Medicine, Centre for PET Austin Hospital, Melbourne, Victoria, Australia.
Issue Date: 2005
Citation: International Psychogeriatrics / Ipa; 17 Suppl 1(): S149-94
Abstract: Several genetic disorders, though rare, are associated or present with dementia. Developments in the field of genetics are contributing to clarify and expand our knowledge of the complex physiopathological mechanisms leading to neurodegeneration and cognitive decline. Disorders associated with misfolded and aggregated proteins and lipid, metal or energy metabolism are examples of the multifarious disease processes converging in the clinical features of dementia, either as its predominant feature, as in cases of Alzheimer's disease (AD) or frontotemporal dementia (FTD), or as part of a cohort of accompanying or late-developing symptoms, as in Parkinson's disease (PD) or amyotrophic lateral sclerosis with dementia (ALS-D). Awareness of these disorders, allied with recent advances in genetic, biochemical and neuroimaging techniques, may lead to early diagnosis, successful treatment and better prognosis.
Internal ID Number: 16240489
URI: http://ahro.austin.org.au/austinjspui/handle/1/10013
URL: http://www.ncbi.nlm.nih.gov/pubmed/16240489
Type: Journal Article
Subjects: Amyotrophic Lateral Sclerosis.complications
Dementia.complications.diagnosis.genetics
Diagnosis, Differential
Energy Metabolism.physiology
Gerstmann-Straussler-Scheinker Disease.genetics
Humans
Huntington Disease.complications
Insomnia, Fatal Familial.complications.genetics
Lipoproteins.metabolism
Nerve Degeneration.complications
Proteins.metabolism
Spinocerebellar Ataxias.complications
Supranuclear Palsy, Progressive.complications
Appears in Collections:Journal articles

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