Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/9994
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dc.contributor.authorMartin, Jarad M-
dc.contributor.authorJoon, Daryl Lim-
dc.contributor.authorNg, Nicole-
dc.contributor.authorGrace, Michael-
dc.contributor.authorGelderen, David Van-
dc.contributor.authorLawlor, Marita-
dc.contributor.authorWada, Morikatsu-
dc.contributor.authorJoon, Michael Lim-
dc.contributor.authorQuong, George-
dc.contributor.authorKhoo, Vincent-
dc.date.accessioned2015-05-15T23:18:05Z
dc.date.available2015-05-15T23:18:05Z
dc.date.issued2005-09-01-
dc.identifier.citationRadiotherapy and Oncology : Journal of the European Society For Therapeutic Radiology and Oncology; 76(3): 251-6en_US
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/9994en
dc.description.abstractAdjuvant radiotherapy is currently standard treatment of Stage I seminoma (SOS). The use of computerised tomogram (CT) planning is compared with traditional planning for greater treatment individualisation.Two plans were generated for each of 10 patients: one using traditional rectangular para-aortic fields, and one using conformal fields. The primary target volume compared was the dosimetric coverage of the inferior vena cava and aorta.The dosimetric analysis of traditional plans showed that they provided reasonable dosimetric coverage of the CTV. However, if 1cm is used for uncertainty based on nodal coverage then the periphery of the PTV could be significantly under-dosed. The CT based plan delivered improved dosimetry to the vessel PTV compared with the traditional field (CT D 95=24.7 Gy, traditional D 95=23.6 Gy, P=0.002). CT-based plans were significantly wider than traditional plans (CT=11.8 cm, traditional=9 cm, P=0.002). The CT plan tended to irradiate relatively small volumes of the kidneys to higher doses.Traditional para-aortic fields may deliver suboptimal dosimetry to an anatomically defined PTV. Our CT-based fields tend to be wider than traditional fields, and provide improved dosimetry to vessels based target volumes. Given that traditional fields are often delivering significantly less than the prescribed dose to the target volume, and that marginal relapses cause a high proportion of treatment failure, there is a suggestion that CT-based plans may avoid under-dosage and geographical miss sometimes seen with traditional plans.en_US
dc.language.isoenen
dc.subject.otherDose Fractionationen
dc.subject.otherHumansen
dc.subject.otherMaleen
dc.subject.otherOrchiectomyen
dc.subject.otherRadiotherapy, Adjuvanten
dc.subject.otherRadiotherapy, Conformal.methodsen
dc.subject.otherRetrospective Studiesen
dc.subject.otherSeminoma.radiotherapy.surgeryen
dc.subject.otherTesticular Neoplasms.radiotherapy.surgeryen
dc.subject.otherTomography, X-Ray Computeden
dc.titleTowards individualised radiotherapy for Stage I seminoma.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleRadiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncologyen_US
dc.identifier.affiliationRadiation Oncologyen_US
dc.identifier.doi10.1016/j.radonc.2005.08.005en_US
dc.description.pages251-6en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/16169622en
dc.type.contentTexten_US
dc.type.austinJournal Articleen
local.name.researcherLawlor, Marita
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
crisitem.author.deptOlivia Newton-John Cancer Wellness and Research Centre-
crisitem.author.deptRadiation Oncology-
crisitem.author.deptOlivia Newton-John Cancer Wellness and Research Centre-
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