Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/9951
Full metadata record
DC FieldValueLanguage
dc.contributor.authorGillies, Michaelen
dc.contributor.authorBellomo, Rinaldoen
dc.contributor.authorDoolan, Laurieen
dc.contributor.authorBuxton, Brian Fen
dc.date.accessioned2015-05-15T23:14:43Z
dc.date.available2015-05-15T23:14:43Z
dc.date.issued2004-12-16en
dc.identifier.citationCritical Care 2004; 9(3): 266-79en
dc.identifier.govdoc15987381en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/9951en
dc.description.abstractMany adult patients require temporary inotropic support after cardiac surgery. We reviewed the literature systematically to establish, present and classify the evidence regarding choice of inotropic drugs. The available evidence, while limited in quality and scope, supports the following observations; although all beta-agonists can increase cardiac output, the best studied beta-agonist and the one with the most favourable side-effect profile appears to be dobutamine. Dobutamine and phosphodiesterase inhibitors (PDIs) are efficacious inotropic drugs for management of the low cardiac output syndrome. Dobutamine is associated with a greater incidence of tachycardia and tachyarrhythmias, whereas PDIs often require the administration of vasoconstrictors. Other catecholamines have no clear advantages over dobutamine. PDIs increase the likelihood of successful weaning from cardiopulmonary bypass as compared with placebo. There is insufficient evidence that inotropic drugs should be selected for their effects on regional perfusion. PDIs also increase flow through arterial grafts, reduce mean pulmonary artery pressure and improve right heart performance in pulmonary hypertension. Insufficient data exist to allow selection of a specific inotropic agent in preference over another in adult cardiac surgery patients. Multicentre randomized controlled trials focusing on clinical rather than physiological outcomes are needed.en
dc.language.isoenen
dc.subject.otherCardiac Output, Low.drug therapyen
dc.subject.otherCardiotonic Agents.classification.therapeutic useen
dc.subject.otherCatecholamines.therapeutic useen
dc.subject.otherCoronary Artery Bypassen
dc.subject.otherDobutamine.adverse effects.therapeutic useen
dc.subject.otherHumansen
dc.subject.otherPhosphodiesterase Inhibitors.therapeutic useen
dc.subject.otherPostoperative Complications.drug therapyen
dc.subject.otherRandomized Controlled Trials as Topicen
dc.subject.otherVentilator Weaningen
dc.titleBench-to-bedside review: Inotropic drug therapy after adult cardiac surgery -- a systematic literature review.en
dc.typeJournal Articleen
dc.identifier.journaltitleCritical Careen
dc.identifier.affiliationDepartment of Intensive Care and Medicine, University of Melbourne, Austin Hospital, Melbourne, Australiaen
dc.identifier.doi10.1186/cc3024en
dc.description.pages266-79en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/15987381en
dc.type.austinJournal Articleen
local.name.researcherBellomo, Rinaldo
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextWith Fulltext-
item.grantfulltextopen-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptIntensive Care-
crisitem.author.deptData Analytics Research and Evaluation (DARE) Centre-
crisitem.author.deptCardiac Surgery-
Appears in Collections:Journal articles
Files in This Item:
File Description SizeFormat 
15987381.pdf134.49 kBAdobe PDFThumbnail
View/Open
Show simple item record

Page view(s)

16
checked on Mar 28, 2024

Download(s)

76
checked on Mar 28, 2024

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.