Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/9950
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dc.contributor.authorSeeman, Egoen
dc.date.accessioned2015-05-15T23:14:38Z
dc.date.available2015-05-15T23:14:38Z
dc.date.issued2005en
dc.identifier.citationJournal of Bone and Mineral Metabolism; 23 Suppl(): 23-9en
dc.identifier.govdoc15984410en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/9950en
dc.description.abstractData from retrospective and prospective observational and case-control studies suggest that activity is associated with reduced fracture risk, but consistently replicated bias may be responsible for this desired endpoint. Exercise during growth is likely to build a larger and stronger skeleton. However, cessation of exercise may erode the benefits. Modeling changes produced by exercise during growth may be permanent; remodeling changes may not be. Exercise during adulthood produces small increments in BMD or may prevent bone loss. Absence of evidence is not evidence of absence of effect, but the null hypothesis that exercise has no effect on fracture rates in old age cannot be rejected by any published data. Proof requires demonstration of a reduction in spine and hip fractures in well-designed and well-executed prospective randomized studies; none exists. Blinded studies cannot be done, but open trials can and should be done.en
dc.language.isoenen
dc.subject.otherAge Factorsen
dc.subject.otherExercise.physiologyen
dc.subject.otherFemaleen
dc.subject.otherFractures, Bone.drug therapy.prevention & controlen
dc.subject.otherHumansen
dc.subject.otherMaleen
dc.subject.otherOsteoporosis.drug therapy.prevention & controlen
dc.subject.otherRisk Factorsen
dc.subject.otherSex Factorsen
dc.titleLoading and bone fragility.en
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of bone and mineral metabolismen
dc.identifier.affiliationEndocrine Unit, Department of Medicine, Austin Hospital, University of Melbourne, Melbourne, Australiaen
dc.description.pages23-9en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/15984410en
dc.type.austinJournal Articleen
local.name.researcherSeeman, Ego
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
crisitem.author.deptEndocrinology-
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