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Title: Ventricular metastasis resulting in disseminated intravascular coagulation.
Austin Authors: John, Thomas ;Davis, Ian D
Ludwig Institute Oncology Unit, Austin Health, Heidelberg, Victoria 3084, Australia
Issue Date: 24-May-2005
Publication information: World Journal of Surgical Oncology 2005; 3(1): 29
Abstract: BACKGROUND: Disseminated Intravascular Coagulation (DIC) complicates up to 7% of malignancies, the commonest solid organ association being adenocarcinoma. Transitional Cell Carcinoma (TCC) has rarely been associated with DIC. CASE PRESENTATION: A 74-year-old woman with TCC bladder and DIC was found to have a cardiac lesion suspicious for metastatic disease. The DIC improved with infusion of plasma and administration of Vitamin K, however the cardiac lesion was deemed inoperable and chemotherapy inappropriate; given the patients functional status. We postulate that direct activation of the coagulation cascade by the intraventricular metastasis probably triggered the coagulopathy in this patient. CONCLUSION: Cardiac metastases should be considered in cancer patients with otherwise unexplained DIC. This may influence treatment choices.
Gov't Doc #: 15913454
DOI: 10.1186/1477-7819-3-29
Type: Journal Article
Appears in Collections:Journal articles

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