Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/9902
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dc.contributor.authorHallam, Karen Ten
dc.contributor.authorOlver, James Sen
dc.contributor.authorNorman, Trevor Ren
dc.date.accessioned2015-05-15T23:10:55Z
dc.date.available2015-05-15T23:10:55Z
dc.date.issued2005-07-01en
dc.identifier.citationNeuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology; 30(7): 1400-4en
dc.identifier.govdoc15841104en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/9902en
dc.description.abstractSensitivity of the pineal hormone melatonin to bright light at night has been proposed as a putative marker of bipolar affective disorder. Patients with bipolar disorder have a super-sensitive melatonin response to light. No studies have investigated whether super-sensitivity is due to agents used to treat the illness or is associated with the disorder per se. We investigated the effect of valproate on this phenomenon. Melatonin sensitivity to light was determined on two nights in 12 healthy volunteers (5M, 7F). Between testing nights participants received 200 mg of valproate b.d. for 5 days. Valproate significantly decreased the sensitivity of melatonin to light. On the other hand, valproate had no effect on overall melatonin secretion or dim light melatonin onset. The ability of valproate to decrease the sensitivity of melatonin to light may relate to its therapeutic effect in bipolar disorder--an ability to lengthen circadian period similar to that of lithium.en
dc.language.isoenen
dc.subject.otherAdolescenten
dc.subject.otherAdulten
dc.subject.otherArea Under Curveen
dc.subject.otherCircadian Rhythm.drug effects.physiology.radiation effectsen
dc.subject.otherFemaleen
dc.subject.otherGABA Agents.pharmacologyen
dc.subject.otherHumansen
dc.subject.otherLighten
dc.subject.otherMaleen
dc.subject.otherMelatonin.blooden
dc.subject.otherPhotic Stimulation.methodsen
dc.subject.otherRadioimmunoassayen
dc.subject.otherValproic Acid.blood.pharmacologyen
dc.titleEffect of sodium valproate on nocturnal melatonin sensitivity to light in healthy volunteers.en
dc.typeJournal Articleen
dc.identifier.journaltitleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacologyen
dc.identifier.affiliationDepartment of Psychiatry, The University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australiaen
dc.identifier.doi10.1038/sj.npp.1300739en
dc.description.pages1400-4en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/15841104en
dc.type.austinJournal Articleen
local.name.researcherNorman, Trevor R
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptPsychiatry (University of Melbourne)-
crisitem.author.deptPsychiatry (University of Melbourne)-
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