Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/9892
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dc.contributor.authorKerr, Fergusen
dc.contributor.authorDawson, Andrewen
dc.contributor.authorWhyte, Ian Men
dc.contributor.authorBuckley, Nicholas Aen
dc.contributor.authorMurray, Lindsayen
dc.contributor.authorGraudins, Andisen
dc.contributor.authorChan, Bettyen
dc.contributor.authorTrudinger, Barbaraen
dc.date.accessioned2015-05-15T23:10:08Z-
dc.date.available2015-05-15T23:10:08Z-
dc.date.issued2005-04-01en
dc.identifier.citationAnnals of Emergency Medicine; 45(4): 402-8en
dc.identifier.govdoc15795719en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/9892en
dc.description.abstractWe determine whether the incidence of adverse events caused by intravenous N -acetylcysteine is significantly less when the initial dose is infused over a 60-minute period compared with the standard infusion period of 15 minutes. A secondary objective is to assess the efficacy of the 2 treatment arms.This was a multicenter, randomized, prospective trial of patients who presented with acetaminophen poisoning and who were treated with N -acetylcysteine and had no history of hypersensitivity to N-acetylcysteine. Patients were randomly assigned to receive the initial dose of N-acetylcysteine over a 15-minute or 60-minute period. Baseline signs and symptoms and adverse events were serially evaluated before and during administration of N -acetylcysteine. Tests of liver injury and coagulation were collected at baseline and then at 12-hour intervals.The study was designed with an 80% power to detect a halving of the incidence of adverse events. Of 180 evaluable patients, 109 patients were randomized to the 15-minute group and 71 patients were randomized to the 60-minute group. The incidence of drug-related adverse events was 45% in the 15-minute group and 38% in the 60-minute group (95% confidence interval -8% to 22%). The study did not demonstrate a reduction of drug-related adverse outcomes with the 60-minute infusion. Incidence of maximum alanine aminotransferase levels indicating hepatotoxicity (serum level >1,000 IU/L) was 6.8% (5.6% for 15-minute, 8.7% for 60-minute). The difference did not attain statistical significance.This study did not demonstrate a reduction of drug-related adverse outcomes with the 60-minute infusion. The study also confirmed that early treatment with N -acetylcysteine (within 8 hours of ingestion) is more effective than later treatment.en
dc.language.isoenen
dc.subject.otherAcetaminophen.blood.poisoningen
dc.subject.otherAcetylcysteine.administration & dosage.adverse effectsen
dc.subject.otherAdulten
dc.subject.otherAlanine Transaminase.blooden
dc.subject.otherAnaphylaxis.chemically induceden
dc.subject.otherAspartate Aminotransferases.blooden
dc.subject.otherDrug Administration Scheduleen
dc.subject.otherDrug-Induced Liver Injuryen
dc.subject.otherFemaleen
dc.subject.otherHumansen
dc.subject.otherInfusions, Intravenousen
dc.subject.otherInternational Normalized Ratioen
dc.subject.otherLiver Diseases.diagnosis.prevention & controlen
dc.subject.otherMaleen
dc.subject.otherNausea.chemically induceden
dc.titleThe Australasian Clinical Toxicology Investigators Collaboration randomized trial of different loading infusion rates of N-acetylcysteine.en
dc.typeJournal Articleen
dc.identifier.journaltitleAnnals of emergency medicineen
dc.identifier.affiliationAustin Health, Heidelberg, Victoria, Australiaen
dc.identifier.doi10.1016/j.annemergmed.2004.08.040en
dc.description.pages402-8en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/15795719en
dc.type.austinJournal Articleen
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.languageiso639-1en-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
crisitem.author.deptVictorian Poisons Information Centre-
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