Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/9861
Full metadata record
DC FieldValueLanguage
dc.contributor.authorCarey, Leeanne Men
dc.contributor.authorAbbott, David Fen
dc.contributor.authorEgan, Gary Fen
dc.contributor.authorBernhardt, Julieen
dc.contributor.authorDonnan, Geoffrey Aen
dc.date.accessioned2015-05-15T23:07:40Z
dc.date.available2015-05-15T23:07:40Z
dc.date.issued2005-01-27en
dc.identifier.citationStroke; A Journal of Cerebral Circulation 2005; 36(3): 625-9en
dc.identifier.govdoc15677574en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/9861en
dc.description.abstractMotor recovery after stroke is associated with cerebral reorganization. However, few studies have investigated the relationship directly, and findings are equivocal. We therefore aimed to characterize the relationship between motor impairment, motor recovery, and task-related changes in regional cerebral blood flow (DeltarCBF) longitudinally.We obtained a profile of motor impairment and recovery in the upper limb and conducted positron emission tomography motor activation studies using a simple finger-tapping task in 9 stroke patients 2 to 7 weeks after stroke and 6 months later. For correlation analysis, mean images of task-related DeltarCBF for each individual were linearly regressed with motor impairment scores. Motor recovery was correlated with longitudinal DeltarCBF images.Patients (7 males; 72.0+/-9.8 years) demonstrated a wide range of impairment severity and variable recovery. Upper-limb motor function was linearly correlated with task-related DeltarCBF. Importantly, sites of correlated DeltarCBF differed over time. Subacutely correlated DeltarCBF was observed in supplementary motor area (SMA), bilateral cingulate, and contralesional insula with a small area in ipsilesional primary sensorimotor cortex (SM1). Conversely, at the 6-month study, correlated DeltarCBF was primarily in ipsilesional SM1, extending to the cingulate gyrus. Better motor recovery was correlated with reduction in contralesional activity and increase in ipsilesional SM1.Upper-limb motor function and recovery are correlated with DeltarCBF in SMA, cingulate, insula, and SM1, highlighting the role of these areas in the recovery process. The dynamic nature of the relationship suggests ongoing adaptation within motor networks.en
dc.language.isoenen
dc.subject.otherAgeden
dc.subject.otherBrain.pathologyen
dc.subject.otherCerebral Cortex.blood supply.pathology.physiopathologyen
dc.subject.otherCerebral Infarction.pathology.physiopathologyen
dc.subject.otherFemaleen
dc.subject.otherHumansen
dc.subject.otherMaleen
dc.subject.otherPositron-Emission Tomography.methodsen
dc.subject.otherPsychomotor Performance.physiologyen
dc.subject.otherRecovery of Function.physiologyen
dc.subject.otherRegional Blood Flow.physiologyen
dc.subject.otherStroke.pathology.physiopathologyen
dc.subject.otherUpper Extremity.physiopathologyen
dc.titleMotor impairment and recovery in the upper limb after stroke: behavioral and neuroanatomical correlates.en
dc.typeJournal Articleen
dc.identifier.journaltitleStrokeen
dc.identifier.affiliationNational Stroke Research Institute, Austin Health, Level 2, Neurosciences Building, Banksia St, Heidelberg West, Victoria, Australia 3081.en
dc.identifier.doi10.1161/01.STR.0000155720.47711.83en
dc.description.pages625-9en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/15677574en
dc.type.austinJournal Articleen
local.name.researcherAbbott, David F
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.languageiso639-1en-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
Appears in Collections:Journal articles
Show simple item record

Page view(s)

16
checked on Mar 27, 2024

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.