Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/9852
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dc.contributor.authorChiang, Cherie Yingen
dc.contributor.authorAndrewes, David Gen
dc.contributor.authorAnderson, Dianneen
dc.contributor.authorDevere, Michaelen
dc.contributor.authorSchweitzer, Isaacen
dc.contributor.authorZajac, Jeffrey Den
dc.date.accessioned2015-05-15T23:06:58Z
dc.date.available2015-05-15T23:06:58Z
dc.date.issued2005-01-01en
dc.identifier.citationClinical Endocrinology; 62(1): 99-104en
dc.identifier.govdoc15638877en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/9852en
dc.description.abstractThere is an increasing number of primary hyperparathyroidism (PHPT) patients with neuropsychological or psychiatric symptoms. Many of these patients do not have osseous or renal complications to satisfy the criteria for parathyroidectomy according to the NIH guidelines.To assess whether there is any improvement in neuropsychological and mood symptoms following parathyroidectomy.Twenty PHPT patients undergoing parathyroidectomy and 20 orthopaedic controls matched for age, gender and estimated intelligence were subjects to pre and postoperative assessment of cognition and mood with a mean surgery-retest interval of 3 months.Using two tests of attentional flexibility [the Stroop test, the Digit symbol test of the Wechsler Adult Intelligence Scale-Revised (WAIS-R)], and two memory tests for prose and nonverbal material, no significant change was found between the groups when comparing scores before and after surgery. There was no improvement between pre and postoperative measures of verbal (dominant hemisphere) as opposed to visuo-spatial (nondominant hemisphere) function when compared to controls. There was no relationship between the reduction in serum calcium and the change in the neuropsychological measures postoperatively.This controlled, prospective study demonstrates no significant improvement in neuropsychological indices using objective, validated psychometric tools in an unselected cohort of PHPT patients. No relationship was found between serum calcium level and the degree of neuropsychological deficit. More studies are needed to assess whether the effect of parathyroidectomy is beneficial and sustainable in PHPT patients with neuropsychological symptoms alone.en
dc.language.isoenen
dc.subject.otherAdulten
dc.subject.otherAffecten
dc.subject.otherAnalysis of Varianceen
dc.subject.otherCase-Control Studiesen
dc.subject.otherCognitionen
dc.subject.otherFemaleen
dc.subject.otherHumansen
dc.subject.otherHyperparathyroidism.psychology.surgeryen
dc.subject.otherMaleen
dc.subject.otherMiddle Ageden
dc.subject.otherNeuropsychological Testsen
dc.subject.otherParathyroidectomyen
dc.subject.otherPostoperative Perioden
dc.subject.otherProspective Studiesen
dc.subject.otherPsychometricsen
dc.subject.otherTreatment Outcomeen
dc.titleA controlled, prospective study of neuropsychological outcomes post parathyroidectomy in primary hyperparathyroid patients.en
dc.typeJournal Articleen
dc.identifier.journaltitleClinical Endocrinologyen
dc.identifier.affiliationEndocrinology Unit, Austin Hospital, Heidelberg Victoria, Australiaen
dc.identifier.doi10.1111/j.1365-2265.2004.02180.xen
dc.description.pages99-104en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/15638877en
dc.type.austinJournal Articleen
item.languageiso639-1en-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
crisitem.author.deptEndocrinology-
crisitem.author.deptMedicine (University of Melbourne)-
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