Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/9700
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dc.contributor.authorRoberts, Matthew Aen
dc.contributor.authorFernando, Den
dc.contributor.authorMacmillan, Nen
dc.contributor.authorProimos, Gen
dc.contributor.authorBach, Leon Aen
dc.contributor.authorPower, David Anthonyen
dc.contributor.authorRatnaike, Sen
dc.contributor.authorIerino, F Len
dc.date.accessioned2015-05-15T22:53:27Z
dc.date.available2015-05-15T22:53:27Z
dc.date.issued2004-01-01en
dc.identifier.citationClinical Nephrology; 61(1): 40-6en
dc.identifier.govdoc14964456en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/9700en
dc.description.abstractCoronary artery disease is the major cause of death in patients with end-stage renal failure on dialysis. This study aimed to assess the predictive value of a single cardiac troponin I (cTnI), and also the kinetics of serial values.Since cTnI is a potential biomarker of cardiac outcome, the present study examined single cTnI measurements (n = 88 patients) and its predictive value for future cardiac events, and a kinetic substudy of serial weekly cTnI measured for 8 weeks (n = 57) in a group of patients on hemodialysis.Single cTnI measurements: 9 patients (10.2%) had a detectable cTnI at baseline and 79 patients (89.8%) had a negative baseline cTnI. There were no significant differences in age, sex, history of ischemic heart disease, diabetes, smoking or dyslipidemia between patients with detectable and negative cTnI. At the end of 9 months, the rate of combined primary endpoints, which included myocardial infarction, cardiac death and cardiac revascularization, was significantly higher in the patients with a detectable baseline cTnI (55.6%), compared to patients with a negative cTnI (6.3%) (p = 0.0007). Serial weekly cTnI measurements: significant fluctuations in cTnI were noted over time; 27% of patients with an undetectable cTnI measured at baseline had subsequent detectable levels in the serial follow-up.A single detectable cTnI in asymptomatic patients on hemodialysis defines patients at high risk of future cardiac events. However, the incidence of detectable cTnI levels is markedly increased when serial weekly measurements are performed. The clinical significance of detectable serial measurements of cTnI is the focus of ongoing studies.en
dc.language.isoenen
dc.subject.otherCoronary Artery Disease.diagnosis.etiologyen
dc.subject.otherFemaleen
dc.subject.otherHumansen
dc.subject.otherMaleen
dc.subject.otherMiddle Ageden
dc.subject.otherPredictive Value of Testsen
dc.subject.otherRenal Dialysis.adverse effectsen
dc.subject.otherTroponin I.analysisen
dc.titleSingle and serial measurements of cardiac troponin I in asymptomatic patients on chronic hemodialysis.en
dc.typeJournal Articleen
dc.identifier.journaltitleClinical nephrologyen
dc.identifier.affiliationDepartment of Nephrology, Austin Health, Heidelberg, Victoria, Australiaen
dc.description.pages40-6en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/14964456en
dc.type.austinJournal Articleen
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
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