Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/9696
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dc.contributor.authorSeeman, Egoen
dc.contributor.authorSzmukler, G Ien
dc.contributor.authorFormica, Cen
dc.contributor.authorTsalamandris, Conen
dc.contributor.authorMestrovic, Ren
dc.date.accessioned2015-05-15T22:53:08Z
dc.date.available2015-05-15T22:53:08Z
dc.date.issued1992-12-01en
dc.identifier.citationJournal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research; 7(12): 1467-74en
dc.identifier.govdoc1481732en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/9696en
dc.description.abstractAnorexia nervosa occurs early in life and predisposes to osteoporosis. Exercise may be protective. We asked: (1) Does failure to attain peak bone density contribute to the deficit in bone density? (2) Does oral contraceptive use protect against osteoporosis? (3) Is any protective effect of exercise confined to weight-bearing sites? Areal bone density (g/cm2) and body composition were measured by dual x-ray absorptiometry in 65 patients with anorexia nervosa and 52 controls. Comparing the 12 patients with primary amenorrhea and the 37 patients with secondary amenorrhea, bone density (mean +/- SEM) at the lumbar spine was 0.88 +/- 0.04 versus 1.06 +/- 0.03 (P = 0.001), respectively. Bone density at the femoral neck was 0.80 +/- 0.04 versus 0.92 +/- 0.03 (P < 0.05), respectively. These values differed before, but not after, adjusting for the respective duration of illness (73.0 +/- 10.3 versus 34.1 +/- 4.8 months, P < 0.001) and fat-free mass (31.6 +/- 1.3 versus 35.4 +/- 0.5 kg, P < 0.01). Bone density at the lumbar spine in the 16 patients with 31.8 +/- 8.3 months of contraceptive exposure was higher than in the 49 patients with no contraceptive exposure (1.14 +/- 0.05 versus 1.02 +/- 0.02 P < 0.02) but was lower than in controls (1.14 +/- 0.05 versus 1.27 +/- 1.02, P < 0.01). No protective effect of contraceptive exposure was detectable at the femoral neck.(ABSTRACT TRUNCATED AT 250 WORDS)en
dc.language.isoenen
dc.subject.otherAmenorrheaen
dc.subject.otherAustraliaen
dc.subject.otherBiologyen
dc.subject.otherBody Weighten
dc.subject.otherCase Control Studiesen
dc.subject.otherComparative Studiesen
dc.subject.otherContraceptionen
dc.subject.otherContraceptive Methods--side effectsen
dc.subject.otherDeficiency Diseasesen
dc.subject.otherDeveloped Countriesen
dc.subject.otherDiseasesen
dc.subject.otherEndocrine Systemen
dc.subject.otherEstrogensen
dc.subject.otherFamily Planningen
dc.subject.otherHormonesen
dc.subject.otherMenstruation Disordersen
dc.subject.otherNutrition Disordersen
dc.subject.otherOceaniaen
dc.subject.otherOral Contraceptives--side effectsen
dc.subject.otherPhysiologyen
dc.subject.otherResearch Methodologyen
dc.subject.otherStudiesen
dc.subject.otherTreatmenten
dc.subject.otherAbsorptiometry, Photonen
dc.subject.otherAdulten
dc.subject.otherAmenorrhea.etiology.physiopathologyen
dc.subject.otherAnorexia Nervosa.complications.physiopathologyen
dc.subject.otherBody Compositionen
dc.subject.otherBone Densityen
dc.subject.otherContraceptives, Oral.pharmacologyen
dc.subject.otherExerciseen
dc.subject.otherFemaleen
dc.subject.otherFemuren
dc.subject.otherHumansen
dc.subject.otherLumbar Vertebraeen
dc.subject.otherOsteoporosis.etiology.physiopathologyen
dc.subject.otherRegression Analysisen
dc.titleOsteoporosis in anorexia nervosa: the influence of peak bone density, bone loss, oral contraceptive use, and exercise.en
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of Bone and Mineral Researchen
dc.identifier.affiliationDepartment of Endocrinology, Austin Hospital, Melbourne, Australiaen
dc.identifier.doi10.1002/jbmr.5650071215en
dc.description.pages1467-74en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/1481732en
dc.type.austinJournal Articleen
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
item.cerifentitytypePublications-
item.grantfulltextnone-
crisitem.author.deptEndocrinology-
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