Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/9681
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dc.contributor.authorHallam, Karen Ten
dc.contributor.authorOlver, James Sen
dc.contributor.authorMcGrath, Carolineen
dc.contributor.authorNorman, Trevor Ren
dc.date.accessioned2015-05-15T22:51:55Z
dc.date.available2015-05-15T22:51:55Z
dc.date.issued2003-12-01en
dc.identifier.citationHuman Psychopharmacology; 18(8): 619-25en
dc.identifier.govdoc14696021en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/9681en
dc.description.abstractTo assess the cognitive and psychomotor effects of single oral doses of valerian in healthy volunteers in comparison with a placebo and the hypnotic agent triazolam.In a double-blind, placebo-controlled, four-way crossover study nine healthy subjects (5 males, 4 females) received in random order valerian 500 mg, valerian 1000 mg, triazolam 0.25 mg and placebo. Doses were separated by a wash-out period of at least 1 week. Subjects were tested before each dose and at 2, 4 and 8 h after the dose of each compound using the critical flicker fusion (CFF), choice reaction time (CRT), digit symbol substitution test (DSST), symbol search test (SST), digit span test (DST) and visual analogue scales of mood.Repeated measures ANOVA was used to examine the changes in performance on tests over time and significant effects were further analysed using simple main effects analysis with least significant difference corrections. Statistically significant differences were only noted for the cognitive tests: SST (F(3, 8)=3.182, p<0.05) and DSST (F(3, 8)=9.688, p<0.005). In both cases the differences between groups were due to the effects of triazolam.These data confirm that at recommended therapeutic doses, triazolam has detrimental effects on cognitive processes in healthy volunteers as found in previous studies. Valerian was without effect on either cognitive or psychomotor performance in healthy volunteers at the doses used in this study. Should the hypnotic activity of valerian be confirmed in randomized double-blind trials it may be a less troublesome alternative to benzodiazepines in the treatment of insomnia.en
dc.language.isoenen
dc.subject.otherAdulten
dc.subject.otherCapsulesen
dc.subject.otherChoice Behavior.drug effectsen
dc.subject.otherCognition.drug effectsen
dc.subject.otherCross-Over Studiesen
dc.subject.otherDose-Response Relationship, Drugen
dc.subject.otherDouble-Blind Methoden
dc.subject.otherFemaleen
dc.subject.otherFlicker Fusion.drug effectsen
dc.subject.otherHumansen
dc.subject.otherMaleen
dc.subject.otherPlant Extracts.pharmacologyen
dc.subject.otherPlant Roots.chemistryen
dc.subject.otherPsychomotor Performance.drug effectsen
dc.subject.otherReaction Time.drug effectsen
dc.subject.otherTriazolam.pharmacologyen
dc.subject.otherValerian.chemistryen
dc.titleComparative cognitive and psychomotor effects of single doses of Valeriana officianalis and triazolam in healthy volunteers.en
dc.typeJournal Articleen
dc.identifier.journaltitleHuman psychopharmacologyen
dc.identifier.affiliationDepartment of Psychiatry, The University of Melbourne, Austin and Repatriation Medical Centre, Heidelberg, Vic 3084, Australiaen
dc.identifier.doi10.1002/hup.542en
dc.description.pages619-25en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/14696021en
dc.type.austinJournal Articleen
local.name.researcherNorman, Trevor R
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptPsychiatry (University of Melbourne)-
crisitem.author.deptPsychiatry (University of Melbourne)-
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