Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/9656
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dc.contributor.authorFilardi, Silvanaen
dc.contributor.authorZebaze, Roger Martin Djoumessien
dc.contributor.authorDuan, Yunboen
dc.contributor.authorEdmonds, Janen
dc.contributor.authorBeck, Thomas Jen
dc.contributor.authorSeeman, Egoen
dc.date.accessioned2015-05-15T22:49:54Z
dc.date.available2015-05-15T22:49:54Z
dc.date.issued2003-11-07en
dc.identifier.citationOsteoporosis International : A Journal Established As Result of Cooperation Between the European Foundation For Osteoporosis and the National Osteoporosis Foundation of The Usa 2003; 15(2): 103-7en
dc.identifier.govdoc14605802en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/9656en
dc.description.abstractTo gain insight into the growth- and age-related origins of bone fragility at the proximal femur, we analyzed structural and biomechanical data of the femoral neck from a study of postmenopausal women with hip fractures and their 47 premenopausal daughters. Results were expressed as standard deviations (SD) or Z-scores (mean +/- SEM) adjusted for age and weight, derived using a normal reference population of 262 premenopausal women and 370 postmenopausal women. Women with hip fractures had increased femoral neck (FN) periosteal and endocortical diameters (1.01 +/- 0.26 SD and 1.18 +/- 0.25 SD, respectively). Cortical thickness was reduced by 0.96 +/- 0.1 SD and volumetric bone mineral density (vBMD) was reduced by 1.2 +/- 0.1 SD). The section modulus was normal while the buckling ratio was increased by 1.59 +/- 0.17 SD). Their daughters had increased FN diameter by about one half that of their mothers (0.48 +/- 0.16 SD), while endocortical diameter was increased by only one third (0.44 +/- 0.13 SD). Cortical thickness and vBMD were not reduced, the section modulus was increased (0.48 +/- 0.13 SD) while the buckling ratio was normal. We infer that the larger femoral neck size in women with hip fractures is growth-related; the wider endocortical cavity and thinner cortex is the result of excessive age-related endocortical bone resorption producing a thin cortex in a larger bone predisposing to structural failure by local buckling. The structural basis of bone fragility has some features originating during growth and others during aging.en
dc.language.isoenen
dc.subject.otherAdulten
dc.subject.otherAgeden
dc.subject.otherAged, 80 and overen
dc.subject.otherAging.physiologyen
dc.subject.otherAnthropometryen
dc.subject.otherBiomechanical Phenomenaen
dc.subject.otherBone Densityen
dc.subject.otherBone Resorption.physiopathologyen
dc.subject.otherFemaleen
dc.subject.otherFemur Neck.growth & development.pathology.physiopathologyen
dc.subject.otherGrowth.geneticsen
dc.subject.otherHip Fractures.genetics.pathology.physiopathologyen
dc.subject.otherHumansen
dc.subject.otherMiddle Ageden
dc.subject.otherPeriosteum.growth & development.physiologyen
dc.subject.otherPostmenopause.physiologyen
dc.subject.otherPremenopause.physiologyen
dc.titleFemoral neck fragility in women has its structural and biomechanical basis established by periosteal modeling during growth and endocortical remodeling during aging.en
dc.typeJournal Articleen
dc.identifier.journaltitleOsteoporosis Internationalen
dc.identifier.affiliationAustin and Repatriation Medical Centre, University of Melbourne, Heidelberg, 3084, Melbourne, Australiaen
dc.identifier.doi10.1007/s00198-003-1539-4en
dc.description.pages103-7en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/14605802en
dc.type.austinJournal Articleen
local.name.researcherSeeman, Ego
item.grantfulltextopen-
item.openairetypeJournal Article-
item.languageiso639-1en-
item.fulltextWith Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
crisitem.author.deptEndocrinology-
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