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DC Field | Value | Language |
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dc.contributor.author | Filardi, Silvana | en |
dc.contributor.author | Zebaze, Roger Martin Djoumessi | en |
dc.contributor.author | Duan, Yunbo | en |
dc.contributor.author | Edmonds, Jan | en |
dc.contributor.author | Beck, Thomas J | en |
dc.contributor.author | Seeman, Ego | en |
dc.date.accessioned | 2015-05-15T22:49:54Z | |
dc.date.available | 2015-05-15T22:49:54Z | |
dc.date.issued | 2003-11-07 | en |
dc.identifier.citation | Osteoporosis International : A Journal Established As Result of Cooperation Between the European Foundation For Osteoporosis and the National Osteoporosis Foundation of The Usa 2003; 15(2): 103-7 | en |
dc.identifier.govdoc | 14605802 | en |
dc.identifier.other | PUBMED | en |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/9656 | en |
dc.description.abstract | To gain insight into the growth- and age-related origins of bone fragility at the proximal femur, we analyzed structural and biomechanical data of the femoral neck from a study of postmenopausal women with hip fractures and their 47 premenopausal daughters. Results were expressed as standard deviations (SD) or Z-scores (mean +/- SEM) adjusted for age and weight, derived using a normal reference population of 262 premenopausal women and 370 postmenopausal women. Women with hip fractures had increased femoral neck (FN) periosteal and endocortical diameters (1.01 +/- 0.26 SD and 1.18 +/- 0.25 SD, respectively). Cortical thickness was reduced by 0.96 +/- 0.1 SD and volumetric bone mineral density (vBMD) was reduced by 1.2 +/- 0.1 SD). The section modulus was normal while the buckling ratio was increased by 1.59 +/- 0.17 SD). Their daughters had increased FN diameter by about one half that of their mothers (0.48 +/- 0.16 SD), while endocortical diameter was increased by only one third (0.44 +/- 0.13 SD). Cortical thickness and vBMD were not reduced, the section modulus was increased (0.48 +/- 0.13 SD) while the buckling ratio was normal. We infer that the larger femoral neck size in women with hip fractures is growth-related; the wider endocortical cavity and thinner cortex is the result of excessive age-related endocortical bone resorption producing a thin cortex in a larger bone predisposing to structural failure by local buckling. The structural basis of bone fragility has some features originating during growth and others during aging. | en |
dc.language.iso | en | en |
dc.subject.other | Adult | en |
dc.subject.other | Aged | en |
dc.subject.other | Aged, 80 and over | en |
dc.subject.other | Aging.physiology | en |
dc.subject.other | Anthropometry | en |
dc.subject.other | Biomechanical Phenomena | en |
dc.subject.other | Bone Density | en |
dc.subject.other | Bone Resorption.physiopathology | en |
dc.subject.other | Female | en |
dc.subject.other | Femur Neck.growth & development.pathology.physiopathology | en |
dc.subject.other | Growth.genetics | en |
dc.subject.other | Hip Fractures.genetics.pathology.physiopathology | en |
dc.subject.other | Humans | en |
dc.subject.other | Middle Aged | en |
dc.subject.other | Periosteum.growth & development.physiology | en |
dc.subject.other | Postmenopause.physiology | en |
dc.subject.other | Premenopause.physiology | en |
dc.title | Femoral neck fragility in women has its structural and biomechanical basis established by periosteal modeling during growth and endocortical remodeling during aging. | en |
dc.type | Journal Article | en |
dc.identifier.journaltitle | Osteoporosis International | en |
dc.identifier.affiliation | Austin and Repatriation Medical Centre, University of Melbourne, Heidelberg, 3084, Melbourne, Australia | en |
dc.identifier.doi | 10.1007/s00198-003-1539-4 | en |
dc.description.pages | 103-7 | en |
dc.relation.url | https://pubmed.ncbi.nlm.nih.gov/14605802 | en |
dc.type.austin | Journal Article | en |
local.name.researcher | Seeman, Ego | |
item.grantfulltext | open | - |
item.openairetype | Journal Article | - |
item.languageiso639-1 | en | - |
item.fulltext | With Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Endocrinology | - |
Appears in Collections: | Journal articles |
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14605802.pdf | 45.53 kB | Adobe PDF | View/Open |
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