Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/9641
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dc.contributor.authorBrodtmann, Amyen
dc.contributor.authorPuce, Ainaen
dc.contributor.authorSyngeniotis, Arien
dc.contributor.authorDarby, David Gen
dc.contributor.authorDonnan, Geoffrey Aen
dc.date.accessioned2015-05-15T22:48:43Z
dc.date.available2015-05-15T22:48:43Z
dc.date.issued2003-09-01en
dc.identifier.citationNeuroimage; 20(1): 520-8en
dc.identifier.govdoc14527612en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/9641en
dc.description.abstractThe effects of aging on blood oxygen level dependent signal changes and the hemodynamic response (HDR) remain controversial. Using functional magnetic resonance (MR) imaging, we examined the HDR properties and activated voxel counts in striate and extrastriate cortex in 18 healthy elderly subjects in response to a simple visual paradigm. Subjects of equal number and gender were prospectively separated into groups from the seventh, eighth, and ninth decades. Activation data were compared with those of 6 healthy subjects aged 30-39 under the same conditions. We found no systematic difference in HDR amplitude, shape, or latency across these groups. However, increasing age over 60 was associated with a significant decline in activated voxel counts, relative to the young controls. The results are discussed in comparison with previously published studies and in the context of the effects of aging on MR signal change. While robust activation can be produced in the striate and extrastriate cortices until the end of the ninth decade, caution should be exercised when comparing data from subjects in different decades. As functional magnetic resonance imaging is increasingly being used to examine patients with stroke and dementia, these results emphasize the importance of careful selection and age matching of control subjects when comparing with a patient population affected by disease processes associated with aging.en
dc.language.isoenen
dc.subject.otherAdulten
dc.subject.otherAgeden
dc.subject.otherAged, 80 and overen
dc.subject.otherAging.physiology.psychologyen
dc.subject.otherCerebrovascular Circulation.physiologyen
dc.subject.otherData Interpretation, Statisticalen
dc.subject.otherFaceen
dc.subject.otherFemaleen
dc.subject.otherHemodynamics.physiologyen
dc.subject.otherHumansen
dc.subject.otherImage Interpretation, Computer-Assisteden
dc.subject.otherMagnetic Resonance Imagingen
dc.subject.otherMaleen
dc.subject.otherMiddle Ageden
dc.subject.otherPhotic Stimulationen
dc.subject.otherSocial Perceptionen
dc.subject.otherVisual Cortex.blood supply.physiologyen
dc.titleThe functional magnetic resonance imaging hemodynamic response to faces remains stable until the ninth decade.en
dc.typeJournal Articleen
dc.identifier.journaltitleNeuroImageen
dc.identifier.affiliationNational Stroke Research Institute, Austin & Repatriation Medical Centre, and Department of Medicien, University of Melbourne, Melbourne, Australiaen
dc.description.pages520-8en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/14527612en
dc.type.austinJournal Articleen
local.name.researcherBrodtmann, Amy
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
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