Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/9565
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dc.contributor.authorMcMahon, L Pen
dc.contributor.authorJohns, J Aen
dc.contributor.authorMcKenzie, Aen
dc.contributor.authorAustin, Men
dc.contributor.authorFowler, Ren
dc.contributor.authorDawborn, J Ken
dc.date.accessioned2015-05-15T22:42:42Z
dc.date.available2015-05-15T22:42:42Z
dc.date.issued1992-05-16en
dc.identifier.citationNephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association; 7(12): 1199-206en
dc.identifier.govdoc1337160en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/9565en
dc.description.abstractPhysical performance and haemodynamic parameters at rest and with exercise were compared in a prospective, cross-over fashion in 12 anaemic haemodialysis patients (Hb 6.4 +/- 0.5, mean +/- SEM) at two levels of haemoglobin (Hb 9 and 12 g/dl) before and after long-term treatment with recombinant human erythropoietin (rHuEpo). Patients were divided into two groups and measurements made prior to treatment, upon reaching, and after 4 months at the first target Hb (9 g/dl group A, 12 g/dl group B), and after 4 months at the alternative target Hb. Tests included an exercise radionuclide ventriculogram, Doppler echocardiogram, and respiratory function exercise test. Compared to pretreatment, there was a significant reduction in resting pulse rate (P < 0.001), and in pulse rate (P < 0.001) and arterial lactate (P < 0.01) concentrations at specified levels of exercise. Work capacity improved 60% (P < 0.001), and left ventricular mass fell by 26% (P < 0.001). Although cardiac output (CO) during and after exercise was reduced (P < 0.05), resting CO, cardiac index, stroke volume and ejection fraction (rest and exercise) were not significantly altered. There appeared little benefit in having the higher target Hb: no significant difference could be found between target levels for almost any measure. In addition, despite marked improvement from pretreatment levels, performance parameters were still below those of non-uraemic age-matched controls. These results demonstrate the beneficial but incomplete effect of rHuEpo on resting and exercise-related factors, and suggest that most improvement is achieved with modest increments in haemoglobin.en
dc.language.isoenen
dc.subject.otherAnemia.blood.drug therapy.physiopathologyen
dc.subject.otherErythropoietin.therapeutic useen
dc.subject.otherExercise.physiologyen
dc.subject.otherHemodynamics.drug effectsen
dc.subject.otherHemoglobins.metabolismen
dc.subject.otherHumansen
dc.subject.otherProspective Studiesen
dc.subject.otherRenal Dialysisen
dc.subject.otherRespiratory Mechanics.drug effectsen
dc.titleHaemodynamic changes and physical performance at comparative levels of haemoglobin after long-term treatment with recombinant erythropoietin.en
dc.typeJournal Articleen
dc.identifier.journaltitleNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Associationen
dc.identifier.affiliationRenal Unit, Austin Hospital, West Heidelberg, Victoria, Australiaen
dc.description.pages1199-206en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/1337160en
dc.type.austinJournal Articleen
item.openairetypeJournal Article-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
item.grantfulltextnone-
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