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DC Field | Value | Language |
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dc.contributor.author | McMahon, L P | en |
dc.contributor.author | Johns, J A | en |
dc.contributor.author | McKenzie, A | en |
dc.contributor.author | Austin, M | en |
dc.contributor.author | Fowler, R | en |
dc.contributor.author | Dawborn, J K | en |
dc.date.accessioned | 2015-05-15T22:42:42Z | |
dc.date.available | 2015-05-15T22:42:42Z | |
dc.date.issued | 1992-05-16 | en |
dc.identifier.citation | Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association; 7(12): 1199-206 | en |
dc.identifier.govdoc | 1337160 | en |
dc.identifier.other | PUBMED | en |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/9565 | en |
dc.description.abstract | Physical performance and haemodynamic parameters at rest and with exercise were compared in a prospective, cross-over fashion in 12 anaemic haemodialysis patients (Hb 6.4 +/- 0.5, mean +/- SEM) at two levels of haemoglobin (Hb 9 and 12 g/dl) before and after long-term treatment with recombinant human erythropoietin (rHuEpo). Patients were divided into two groups and measurements made prior to treatment, upon reaching, and after 4 months at the first target Hb (9 g/dl group A, 12 g/dl group B), and after 4 months at the alternative target Hb. Tests included an exercise radionuclide ventriculogram, Doppler echocardiogram, and respiratory function exercise test. Compared to pretreatment, there was a significant reduction in resting pulse rate (P < 0.001), and in pulse rate (P < 0.001) and arterial lactate (P < 0.01) concentrations at specified levels of exercise. Work capacity improved 60% (P < 0.001), and left ventricular mass fell by 26% (P < 0.001). Although cardiac output (CO) during and after exercise was reduced (P < 0.05), resting CO, cardiac index, stroke volume and ejection fraction (rest and exercise) were not significantly altered. There appeared little benefit in having the higher target Hb: no significant difference could be found between target levels for almost any measure. In addition, despite marked improvement from pretreatment levels, performance parameters were still below those of non-uraemic age-matched controls. These results demonstrate the beneficial but incomplete effect of rHuEpo on resting and exercise-related factors, and suggest that most improvement is achieved with modest increments in haemoglobin. | en |
dc.language.iso | en | en |
dc.subject.other | Anemia.blood.drug therapy.physiopathology | en |
dc.subject.other | Erythropoietin.therapeutic use | en |
dc.subject.other | Exercise.physiology | en |
dc.subject.other | Hemodynamics.drug effects | en |
dc.subject.other | Hemoglobins.metabolism | en |
dc.subject.other | Humans | en |
dc.subject.other | Prospective Studies | en |
dc.subject.other | Renal Dialysis | en |
dc.subject.other | Respiratory Mechanics.drug effects | en |
dc.title | Haemodynamic changes and physical performance at comparative levels of haemoglobin after long-term treatment with recombinant erythropoietin. | en |
dc.type | Journal Article | en |
dc.identifier.journaltitle | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association | en |
dc.identifier.affiliation | Renal Unit, Austin Hospital, West Heidelberg, Victoria, Australia | en |
dc.description.pages | 1199-206 | en |
dc.relation.url | https://pubmed.ncbi.nlm.nih.gov/1337160 | en |
dc.type.austin | Journal Article | en |
item.openairetype | Journal Article | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
Appears in Collections: | Journal articles |
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