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dc.contributor.authorJandeleit, Ken
dc.contributor.authorPerich, Ren
dc.contributor.authorJackson, Ben
dc.contributor.authorJohnston, Colin Ien
dc.identifier.citationClinical and Experimental Pharmacology & Physiology; 19(5): 348-52en
dc.description.abstract1. Angiotensin-converting enzyme (ACE) concentration was measured in mesenteric and brain microvessels from spontaneously hypertensive rats (SHR) and compared with normotensive controls using a specific radioligand binding assay. 2. Plasma angiotensin-converting enzyme activity was similar in SHR (n = 15) and normotensive controls (n = 21; 58 +/- 1 nmol HL/mL per min, vs 64 +/- 6 nmol HL/mL per min). 3. There was no significant difference between the mesenteric vascular angiotensin-converting enzyme radioligand binding site density (Bmax, fmol/mg protein) of SHR and normotensive controls (954 +/- 77 vs 890 +/- 56, P = 0.5, unpaired Student's t-test), despite significant differences in systolic blood pressure (220 +/- 8 mm Hg vs 120 +/- 6 mm Hg respectively, P less than 0.01) and increased mesenteric wet weight to bodyweight ratio in the hypertensive rats (0.28 +/- 0.02 mg/g, n = 5 vs 0.16 +/- 0.02 mg/g, n = 7, P less than 0.01). 4. Brain vascular angiotensin-converting enzyme radioligand binding site density (Bmax, fmol/mg protein) was also similar in SHR and normotensive controls (467 +/- 62, n = 5 vs 497 +/- 64, n = 5, P = 0.7, unpaired Student's t-test). 5. These results demonstrate that vascular angiotensin-converting enzyme concentration is not altered in the SHR and that vascular ACE is not increased in this form of vascular hypertrophy or regulated by the blood pressure level.en
dc.subject.otherBody Weight.physiologyen
dc.subject.otherBrain.blood supply.enzymologyen
dc.subject.otherCerebral Arteries.enzymology.pathologyen
dc.subject.otherCerebral Veins.enzymology.pathologyen
dc.subject.otherMesenteric Arteries.anatomy & histology.enzymology.pathologyen
dc.subject.otherMesenteric Veins.anatomy & histology.enzymology.pathologyen
dc.subject.otherPeptidyl-Dipeptidase A.blood.metabolismen
dc.subject.otherRats, Inbred SHRen
dc.subject.otherRats, Inbred WKYen
dc.subject.otherVascular Resistance.physiologyen
dc.titleMesenteric resistance and brain microvascular angiotensin-converting enzyme in the spontaneously hypertensive rat.en
dc.typeJournal Articleen
dc.identifier.journaltitleClinical and Experimental Pharmacology & Physiologyen
dc.identifier.affiliationDepartment of Medicine, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australiaen
dc.type.austinJournal Articleen
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
item.languageiso639-1en- and Hepatology-
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