Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/9504
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dc.contributor.authorWellard, R Marken
dc.contributor.authorBriellmann, Regula Sen
dc.contributor.authorPrichard, James Wen
dc.contributor.authorSyngeniotis, Arien
dc.contributor.authorJackson, Graeme Den
dc.date.accessioned2015-05-15T22:37:22Z
dc.date.available2015-05-15T22:37:22Z
dc.date.issued2003-06-01en
dc.identifier.citationEpilepsia; 44(6): 815-21en
dc.identifier.govdoc12790895en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/9504en
dc.description.abstractThis study used magnetic resonance spectroscopy (MRS) to examine metabolite abnormalities in the temporal and frontal lobe of patients with temporal lobe epilepsy (TLE) of differing severity.We investigated myoinositol in TLE by using short-echo MRS in 34 TLE patients [26 late onset (LO-TLE), eight hippocampal sclerosis (HS-TLE)], and 16 controls. Single-voxel short-echo (35 ms) MR spectra of temporal and frontal lobes were acquired at 1.5 T and analyzed by using LCModel.The temporal lobe ipsilateral to seizure origin in HS-TLE, but not LO-TLE, had reduced N-acetylaspartate (NA) and elevated myoinositol (MI; HS-TLE NA, 7.8 +/- 1.9 mM, control NA, 9.2 +/- 1.3 mM; p < 0.05; HS-TLE MI, 6.1 +/- 1.6 mM, control mI 4.9 +/- 0.8 mM, p< 0.05). Frontal lobe MI was low in both patient groups (LO-TLE, 4.3 +/- 0.8 mM; p < 0.05; HS-TLE, 3.6 +/-.05 mM; p < 0.001; controls, 4.8 +/- 0.5 mM). Ipsilateral frontal lobes had lower MI (3.8 +/- 0.7 mM; p < 0.01) than contralateral frontal lobes (4.3 +/- 0.8 mM; p < 0.05).MI changes may distinguish between the seizure focus, where MI is increased, and areas of seizure spread where MI is decreased.en
dc.language.isoenen
dc.subject.otherAdulten
dc.subject.otherAge of Onseten
dc.subject.otherAspartic Acid.analogs & derivatives.metabolismen
dc.subject.otherEpilepsy, Temporal Lobe.diagnosis.metabolismen
dc.subject.otherFemaleen
dc.subject.otherFrontal Lobe.metabolismen
dc.subject.otherFunctional Lateralityen
dc.subject.otherHippocampus.metabolism.pathologyen
dc.subject.otherHumansen
dc.subject.otherInositol.metabolismen
dc.subject.otherMagnetic Resonance Spectroscopyen
dc.subject.otherMaleen
dc.subject.otherSclerosisen
dc.subject.otherTemporal Lobe.metabolismen
dc.titleMyoinositol abnormalities in temporal lobe epilepsy.en
dc.typeJournal Articleen
dc.identifier.journaltitleEpilepsiaen
dc.identifier.affiliationBrain Research Institute University of Melbourne, Austin and Repatriation Medical Center, Heidelberg West, Australiaen
dc.description.pages815-21en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/12790895en
dc.type.austinJournal Articleen
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.languageiso639-1en-
crisitem.author.deptNeurology-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
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