Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/9413
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dc.contributor.authorBonnet, Fabriceen
dc.contributor.authorTikellis, Christosen
dc.contributor.authorKawachi, Hiroshien
dc.contributor.authorBurns, Wendy Cen
dc.contributor.authorWookey, Peter Jen
dc.contributor.authorCao, Zeminen
dc.contributor.authorCooper, Mark Een
dc.date.accessioned2015-05-15T22:29:56Z
dc.date.available2015-05-15T22:29:56Z
dc.date.issued2002-07-01en
dc.identifier.citationClinical and Experimental Hypertension (new York, N.y. : 1993); 24(5): 371-81en
dc.identifier.govdoc12109777en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/9413en
dc.description.abstractNephrin is a slit diaphragm protein and its expression in the developing kidney is largely unknown. In this study, we explored the expression of nephrin in the developmental kidney in spontaneously hypertensive (SHR) and in Wistar-Kyoto (WKY) rats at different time points, from day 5 after birth to adulthood. Real time RT-PCR, in situ hybridization and immunohistochemistry were used to assess and quantify gene and protein expression of nephrin in the kidney. SHR had hypertension at week 10 and albuminuria at week 20. Nephrin expression in both SHR and WKY increased from day 5 to adulthood. Furthermore, both gene and protein expression of nephrin were significantly lower in SHR after birth when compared to WKY at the same age. These findings suggest that both in normotensive and hypertensive rats, nephrin expression increased from birth to the adult age and that down-regulation of nephrin in SHR evident from the early developmental kidney to adulthood may contribute to the development of albuminuria in adult SHR.en
dc.language.isoenen
dc.subject.otherAlbuminuria.physiopathologyen
dc.subject.otherAnimalsen
dc.subject.otherBlood Pressureen
dc.subject.otherGene Expression Regulation, Developmentalen
dc.subject.otherHypertension.physiopathologyen
dc.subject.otherIn Situ Hybridizationen
dc.subject.otherKidney.chemistry.growth & development.physiologyen
dc.subject.otherMaleen
dc.subject.otherMembrane Proteinsen
dc.subject.otherProteins.analysis.geneticsen
dc.subject.otherRNA, Messenger.analysisen
dc.subject.otherRatsen
dc.subject.otherRats, Inbred SHRen
dc.subject.otherRats, Inbred WKYen
dc.titleNephrin expression in the post-natal developing kidney in normotensive and hypertensive rats.en
dc.typeJournal Articleen
dc.identifier.journaltitleClinical and experimental hypertension (New York, N.Y. : 1993)en
dc.identifier.affiliationDepartment of Medicine, University of Melbourne, Austin & Repatriation Medical Centre, Heidelberg West, Victoria, Australiaen
dc.description.pages371-81en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/12109777en
dc.type.austinJournal Articleen
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptMedicine (University of Melbourne)-
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