Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/9350
Full metadata record
DC FieldValueLanguage
dc.contributor.authorDinh, Diem Ten
dc.contributor.authorFrauman, Albert Gen
dc.contributor.authorCasley, David Jen
dc.contributor.authorJohnston, Colin Ien
dc.contributor.authorFabiani, Mark Een
dc.date.accessioned2015-05-15T22:24:54Z
dc.date.available2015-05-15T22:24:54Z
dc.date.issued2001-11-26en
dc.identifier.citationMolecular and Cellular Endocrinology; 184(1-2): 187-92en
dc.identifier.govdoc11694354en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/9350en
dc.description.abstractThe cellular localisation and expression of angiotensin AT(4) receptors was examined in the normal human prostate and benign prostatic hyperplasia (BPH) by quantitative in vitro autoradiography using [(125)I]-Ang IV. In the normal human prostate, AT(4) receptors were localised to the glandular epithelium. Interestingly, specific AT(4) receptor binding was significantly reduced in BPH compared to the normal prostate, as quantitated macroscopically (normal: 5038+/-476 dpm/mm(2), n=6 vs BPH: 2701+/-176 dpm/mm(2), n=6, P<0.001) and microscopically (normal: 7.28+/-0.36 grains/mm(2), n=6 vs BPH: 2.50+/-0.47 grains/mm(2), n=6, P<0.001). The findings of the present study demonstrate the presence of AT(4) receptors in the human prostate, being localised to the glandular epithelium, which suggest that the Ang IV/AT(4) system may play a role in the regulation of ionic transport and glandular secretion in the human prostate. The observation that AT(4) receptors appear reduced in BPH suggests that the AT(4) receptor may undergo agonist-induced receptor internalisation, possibly due to increased local tissue levels of Ang IV in BPH.en
dc.language.isoenen
dc.subject.otherAutoradiographyen
dc.subject.otherEpithelial Cells.chemistryen
dc.subject.otherHumansen
dc.subject.otherIodine Radioisotopes.diagnostic useen
dc.subject.otherMaleen
dc.subject.otherProstate.chemistry.cytologyen
dc.subject.otherProstatic Hyperplasia.metabolism.pathologyen
dc.subject.otherProtein Bindingen
dc.subject.otherReceptors, Angiotensin.analysis.metabolismen
dc.subject.otherTissue Distributionen
dc.titleAngiotensin AT(4) receptors in the normal human prostate and benign prostatic hyperplasia.en
dc.typeJournal Articleen
dc.identifier.journaltitleMolecular and cellular endocrinologyen
dc.identifier.affiliationDepartment of Medicine & Clinical Pharmacology & Therapeutics Unit, Austin & Repatriation Medical Centre, University of Melbourne,. Heidelberg VIC. 3084, Australiaen
dc.description.pages187-92en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/11694354en
dc.type.austinJournal Articleen
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.languageiso639-1en-
crisitem.author.deptClinical Pharmacology and Therapeutics-
Appears in Collections:Journal articles
Show simple item record

Page view(s)

16
checked on Jan 30, 2023

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.