Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/9290
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dc.contributor.authorDinh, Diem Ten
dc.contributor.authorFrauman, Albert Gen
dc.contributor.authorSourial, Men
dc.contributor.authorCasley, David Jen
dc.contributor.authorJohnston, Colin Ien
dc.contributor.authorFabiani, Mark Een
dc.date.accessioned2015-05-15T22:19:25Z
dc.date.available2015-05-15T22:19:25Z
dc.date.issued2001-03-01en
dc.identifier.citationEndocrinology; 142(3): 1349-56en
dc.identifier.govdoc11181554en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/9290en
dc.description.abstractThe tissue distribution, cellular localization, and level of expression of angiotensin II (Ang II) receptors were examined in the normal human prostate and benign prostatic hyperplasia (BPH) by in vitro autoradiography, immunohistochemistry, and radioligand binding studies. In the normal human prostate, Ang II receptors were of the AT(1) subtype and localized predominantly to periurethral stromal smooth muscle. The AT(1) receptor antagonist losartan totally displaced specific [(125)I]-[Sar(1),Ile(8)]Ang II binding, in a concentration-dependent manner, whereas the AT(2) receptor antagonist PD123319 was without effect. There was no significant difference in receptor affinity, but AT(1) receptor density was markedly reduced in BPH compared with that in normal prostate. In rat prostate, Ang II (0.01-1 microM) produced a concentration-dependent increase in [(3)H]-noradrenaline release from sympathetic nerves. The findings of the present study suggest that angiotensin AT(1) receptors predominate in the human prostate. The high concentration of AT(1) receptors in the periurethral region suggests a role for Ang II in modulating cell growth, smooth muscle tone, and possibly micturition. Furthermore, down-regulation of AT(1) receptors in BPH may be due to receptor hyperstimulation by increased local levels of Ang II in BPH. Finally, Ang II may play a functional role in modulating sympathetic transmission in the prostate. These data support the novel concept that activation of the renin-angiotensin system may be involved in the pathophysiology of BPH.en
dc.language.isoenen
dc.subject.otherAutoradiographyen
dc.subject.otherBinding, Competitiveen
dc.subject.otherHumansen
dc.subject.otherImmunohistochemistryen
dc.subject.otherMaleen
dc.subject.otherMembranes.metabolismen
dc.subject.otherMiddle Ageden
dc.subject.otherNorepinephrine.metabolismen
dc.subject.otherProstate.metabolismen
dc.subject.otherProstatic Hyperplasia.metabolismen
dc.subject.otherReceptors, Angiotensin.metabolismen
dc.subject.otherReference Valuesen
dc.subject.otherTissue Distributionen
dc.titleIdentification, distribution, and expression of angiotensin II receptors in the normal human prostate and benign prostatic hyperplasia.en
dc.typeJournal Articleen
dc.identifier.journaltitleEndocrinologyen
dc.identifier.affiliationDepartment of Medicine, University of Melbourne, Austin and Repatriation Medical Centre, Heidelberg, Victoria 3084, Australiaen
dc.identifier.doi10.1210/endo.142.3.8020en
dc.description.pages1349-56en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/11181554en
dc.type.austinJournal Articleen
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptClinical Pharmacology and Therapeutics-
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