Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/9274
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dc.contributor.authorBriellmann, Regula Sen
dc.contributor.authorBerkovic, Samuel Fen
dc.contributor.authorJackson, Graeme Den
dc.date.accessioned2015-05-15T22:18:12Z
dc.date.available2015-05-15T22:18:12Z
dc.date.issued2000-11-28en
dc.identifier.citationNeurology; 55(10): 1479-85en
dc.identifier.govdoc11094101en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/9274en
dc.description.abstractRepetitive seizures may be associated with progressive neuronal damage measurable by quantitative MRI.To investigate whether gender is a risk factor for this damage.Sixty patients with refractory temporal lobe epilepsy (TLE) (28 men, 32 women) and 54 healthy controls (28 men, 26 women) were compared by quantitative MRI methods.Male patients had ipsilateral hemicranial volume loss of 12% (CI 8% to 16%) and contralateral volume loss of 7% (CI:3% to 11%) compared with male controls (p < or =0.004, analysis of variance). Female patients were 4% (CI:0.3% to 8%, p = 0.04) smaller than controls in the ipsilateral hemicranium, and not different contralaterally. The patient-to-control difference was greater in men than in women for the ipsilateral (p = 0.003) and contralateral hemicranial volume (p = 0.02). In men, 14% of the ipsilateral (F = 4.7, p = 0.004) and 16% of the contralateral (F = 5.1, p = 0.03) hemicranial volume loss could be attributed to generalized tonic clonic seizures. Compared with controls, patients averaged a 29% smaller ipsilateral and a 5% smaller contralateral hippocampus.Men with TLE have more brain atrophy than women with TLE. Seizure frequency is a factor contributing to reduced brain volumes in men but not in women. Men, therefore, may be more vulnerable to seizure-associated brain abnormalities.en
dc.language.isoenen
dc.subject.otherAdulten
dc.subject.otherBrain Diseases.etiology.pathologyen
dc.subject.otherEpilepsy, Temporal Lobe.complications.pathologyen
dc.subject.otherFemaleen
dc.subject.otherHumansen
dc.subject.otherMagnetic Resonance Imagingen
dc.subject.otherMaleen
dc.subject.otherMiddle Ageden
dc.subject.otherRisk Factorsen
dc.subject.otherSex Distributionen
dc.titleMen may be more vulnerable to seizure-associated brain damage.en
dc.typeJournal Articleen
dc.identifier.journaltitleNeurologyen
dc.identifier.affiliationBrain Research Institute, and Department of Neurology, Austin and Repatriation Medical Center and Department of Medicine, University of Melbourne, Victoria, Australiaen
dc.description.pages1479-85en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/11094101en
dc.type.austinJournal Articleen
local.name.researcherBerkovic, Samuel F
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
crisitem.author.deptEpilepsy Research Centre-
crisitem.author.deptNeurology-
crisitem.author.deptNeurology-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
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