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Title: Antidepressants and breast-feeding: a review of the literature.
Austin Authors: Dodd, Seetal;Buist, Anne ;Norman, Trevor R 
Affiliation: Department of Psychiatry, University of Melbourne, Austin & Repatriation Medical Centre, Heidelberg, Australia
Issue Date: 6-May-2000
Publication information: Paediatric Drugs; 2(3): 183-92
Abstract: For every antidepressant so far investigated in the breast milk of mothers prescribed these medications, findings indicate that some amount of drug will be excreted into the breast milk. Nursing infants will be exposed to some, usually a very low, amount of drug and drug metabolites. Levels of drug exposure to infants for the many antidepressants available are examined, discussing milk to plasma drug concentration ratios and the infant dose as a percentage of the maternal dose. Drug concentrations in infant plasma and adverse effects of drug exposures to infants are reviewed. Factors influencing the decision on whether to breast or bottle feed an infant nursed by a mother taking antidepressants are discussed, concluding that the decision needs to be made on an individual basis. The lactating mother, in consultation with her doctor, should be in a position to make an informed decision on whether or not to breast feed. Under certain circumstances the decision to bottle feed may be wise, but more commonly the advantages of breast-feeding will outweigh the very low risk of an adverse event from drug exposure to the infant.
Gov't Doc #: 10937469
Type: Journal Article
Subjects: Adult
Antidepressive Agents.adverse effects.blood.pharmacokinetics
Breast Feeding.adverse effects
Infant, Newborn
Milk, Human.metabolism
Appears in Collections:Journal articles

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