Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/9238
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dc.contributor.authorSingh, Ren
dc.contributor.authorMacdonell, Richard A Len
dc.contributor.authorScheffer, Ingrid Een
dc.contributor.authorCrossland, Kathryn Men
dc.contributor.authorBerkovic, Samuel Fen
dc.date.accessioned2015-05-15T22:15:17Z
dc.date.available2015-05-15T22:15:17Z
dc.date.issued1999-06-01en
dc.identifier.citationEpileptic Disorders : International Epilepsy Journal With Videotape; 1(2): 93-9en
dc.identifier.govdoc10937138en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/9238en
dc.description.abstractThe epilepsies have been regarded as clinically distinct from the paroxysmal movement disorders. Recently, a variety of ion channel defects have been identified as the biological basis of certain familial epilepsies and paroxysmal movement disorders. We studied two families with the co-occurrence of epilepsy, movement disorders and migraine. Information was obtained on 147 individuals in the two families. In family WF, there was a co-occurrence of epilepsy (benign infantile convulsions, idiopathic generalized epilepsy), episodic ataxia (with cerebellar atrophy and without myokymia) and common migraine. In family CL, epilepsy (febrile seizures, febrile seizures plus), kinesigenic paroxysmal dyskinesia and migraine (including hemiplegic migraine) were observed in various combinations over 3 generations. The observations in these two families, together with review of the literature, suggest that the co-occurrence of epilepsy (particularly benign infantile convulsions), paroxysmal movement disorders and migraine is not due to chance. Thus, these distinct clinical phenomena could have a shared biological basis and ion channel defects are an attractive possibility.en
dc.language.isoenen
dc.subject.otherAdolescenten
dc.subject.otherAdulten
dc.subject.otherChorea.diagnosis.geneticsen
dc.subject.otherDiseases in Twins.geneticsen
dc.subject.otherEpilepsy.diagnosis.geneticsen
dc.subject.otherFemaleen
dc.subject.otherFollow-Up Studiesen
dc.subject.otherHemiplegia.diagnosis.geneticsen
dc.subject.otherHumansen
dc.subject.otherInfanten
dc.subject.otherMaleen
dc.subject.otherMiddle Ageden
dc.subject.otherMigraine Disorders.diagnosis.geneticsen
dc.subject.otherPedigreeen
dc.subject.otherPhenotypeen
dc.subject.otherSpinocerebellar Degenerations.diagnosis.geneticsen
dc.titleEpilepsy and paroxysmal movement disorders in families: evidence for shared mechanisms.en
dc.typeJournal Articleen
dc.identifier.journaltitleEpileptic disorders : international epilepsy journal with videotapeen
dc.identifier.affiliationDepartment of Medicine (Neurology), University of Melbourne, Austin, Australiaen
dc.description.pages93-9en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/10937138en
dc.type.austinJournal Articleen
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptNeurology-
crisitem.author.deptEpilepsy Research Centre-
crisitem.author.deptEpilepsy Research Centre-
crisitem.author.deptNeurology-
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