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Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/35540
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dc.contributor.authorMuhi, Stephen-
dc.contributor.authorMarshall, Julia L-
dc.contributor.authorO'Brien, Daniel P-
dc.contributor.authorJohnson, Paul D R-
dc.contributor.authorRoss, Gayle-
dc.contributor.authorRamakrishnan, Anand-
dc.contributor.authorMackay, Laura K-
dc.contributor.authorDoerflinger, Marcel-
dc.contributor.authorMcCarthy, James S-
dc.contributor.authorJamrozik, Euzebiusz-
dc.contributor.authorOsowicki, Joshua-
dc.contributor.authorStinear, Timothy P-
dc.date2024-
dc.date.accessioned2024-10-21T03:53:54Z-
dc.date.available2024-10-21T03:53:54Z-
dc.date.issued2024-
dc.identifier.citationWellcome Open Research 2024; 9en_US
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/35540-
dc.description.abstractCritical knowledge gaps have impeded progress towards reducing the global burden of disease due to Mycobacterium ulcerans, the cause of the neglected tropical disease Buruli ulcer (BU). Development of a controlled human infection model of BU has been proposed as an experimental platform to explore host-pathogen interactions and evaluate tools for prevention, diagnosis, and treatment. We have previously introduced the use case for a new human model and identified M. ulcerans JKD8049 as a suitable challenge strain. Here, we present a provisional protocol for an initial study, for transparent peer review during the earliest stages of protocol development. Following simultaneous scientific peer review and community/stakeholder consultation of this provisional protocol, we aim to present a refined protocol for institutional review board (IRB) evaluation.en_US
dc.language.isoeng-
dc.subjectBairnsdale ulceren_US
dc.subjectBuruli ulceren_US
dc.subjectM. ulceransen_US
dc.subjectMycobacterium ulceransen_US
dc.subjectcontrolled human infection modelen_US
dc.titleA human model of Buruli ulcer: Provisional protocol for a Mycobacterium ulcerans controlled human infection study.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleWellcome Open Researchen_US
dc.identifier.affiliationDepartment of Microbiology and Immunology, Doherty Institute, University of Melbourne, Melbourne, Victoria, 3000, Australia.;Victorian Infectious Diseases Service, The Royal Melbourne Hospital, Parkville, Victoria, Australia.;Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.;Department of General Medicine, The Royal Melbourne Hospital, Parkville, Victoria, Australia.en_US
dc.identifier.affiliationDepartment of Infectious Diseases, Doherty Institute, University of Melbourne, Melbourne, Victoria, Australia.en_US
dc.identifier.affiliationVictorian Infectious Diseases Service, The Royal Melbourne Hospital, Parkville, Victoria, Australia.;Department of Infectious Diseases, Doherty Institute, University of Melbourne, Melbourne, Victoria, Australia.;Department of Infectious Diseases, Barwon Health, Geelong, Victoria, Australia.en_US
dc.identifier.affiliationDepartment of Microbiology and Immunology, Doherty Institute, University of Melbourne, Melbourne, Victoria, 3000, Australia.;Austin Health, Heidelberg, Victoria, Australia.en_US
dc.identifier.affiliationDepartment of Dermatology, The Royal Melbourne Hospital, Parkville, Victoria, Australia.en_US
dc.identifier.affiliationDepartment of Plastic and Reconstructive Surgery, The Royal Melbourne Hospital, Parkville, Victoria, Australia.en_US
dc.identifier.affiliationDepartment of Microbiology and Immunology, Doherty Institute, University of Melbourne, Melbourne, Victoria, 3000, Australia.en_US
dc.identifier.affiliationWalter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.;Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.en_US
dc.identifier.affiliationVictorian Infectious Diseases Service, The Royal Melbourne Hospital, Parkville, Victoria, Australia.;Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.;Department of Infectious Diseases, Doherty Institute, University of Melbourne, Melbourne, Victoria, Australia.en_US
dc.identifier.affiliationDepartment of General Medicine, The Royal Melbourne Hospital, Parkville, Victoria, Australia.;WHO Collaborating Centre for Bioethics, Monash University, Clayton, Victoria, Australia.en_US
dc.identifier.affiliationTropical Diseases Research Group, Murdoch Children's Research Institute, The Royal Children's Hospital, Parkville, Victoria, Australia.;Infectious Diseases Unit, Department of General Medicine, The Royal Children's Hospital, Parkville, Victoria, Australia.;Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia.en_US
dc.identifier.affiliationDepartment of Microbiology and Immunology, Doherty Institute, University of Melbourne, Melbourne, Victoria, 3000, Australia.;WHO Collaborating Centre for Mycobacterium ulcerans, Doherty Institute, Melbourne, Victoria, Australia.en_US
dc.identifier.affiliationThe Peter Doherty Instituteen_US
dc.identifier.doi10.12688/wellcomeopenres.22719.1en_US
dc.type.contentTexten_US
dc.identifier.orcid0000-0001-9873-7163en_US
dc.identifier.orcid0000-0001-5750-1920en_US
dc.identifier.orcid0000-0001-5540-8124en_US
dc.identifier.orcid0000-0001-6596-9718en_US
dc.identifier.orcid0000-0001-5940-602Xen_US
dc.identifier.orcid0000-0002-9432-6700en_US
dc.identifier.orcid0000-0003-0150-123Xen_US
dc.identifier.pubmedid39386965-
dc.description.volume9-
dc.description.startpage488-
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
crisitem.author.deptInfectious Diseases-
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