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Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/35478
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dc.contributor.authorJia, Xiaoxiao-
dc.contributor.authorCrawford, Jeremy Chase-
dc.contributor.authorGebregzabher, Deborah-
dc.contributor.authorMonson, Ebony A-
dc.contributor.authorMettelman, Robert C-
dc.contributor.authorWan, Yanmin-
dc.contributor.authorRen, Yanqin-
dc.contributor.authorChou, Janet-
dc.contributor.authorNovak, Tanya-
dc.contributor.authorMcQuilten, Hayley A-
dc.contributor.authorClarke, Michele-
dc.contributor.authorBachem, Annabell-
dc.contributor.authorFoo, Isabelle J-
dc.contributor.authorFritzlar, Svenja-
dc.contributor.authorCarrera Montoya, Julio-
dc.contributor.authorTrenerry, Alice M-
dc.contributor.authorNie, Shuai-
dc.contributor.authorLeeming, Michael G-
dc.contributor.authorNguyen, Thi H O-
dc.contributor.authorKedzierski, Lukasz-
dc.contributor.authorLittler, Dene R-
dc.contributor.authorKueh, Andrew-
dc.contributor.authorCardamone, Tina-
dc.contributor.authorWong, Chinn Yi-
dc.contributor.authorHensen, Luca-
dc.contributor.authorCabug, Aira-
dc.contributor.authorLaguna, Jaime Gómez-
dc.contributor.authorAgrawal, Mona-
dc.contributor.authorFlerlage, Tim-
dc.contributor.authorBoyd, David F-
dc.contributor.authorVan de Velde, Lee-Ann-
dc.contributor.authorHabel, Jennifer R-
dc.contributor.authorLoh, Liyen-
dc.contributor.authorKoay, Hui-Fern-
dc.contributor.authorvan de Sandt, Carolien E-
dc.contributor.authorKonstantinov, Igor E-
dc.contributor.authorBerzins, Stuart P-
dc.contributor.authorFlanagan, Katie L-
dc.contributor.authorWakim, Linda M-
dc.contributor.authorHerold, Marco J-
dc.contributor.authorGreen, Amanda M-
dc.contributor.authorSmallwood, Heather S-
dc.contributor.authorRossjohn, Jamie-
dc.contributor.authorThwaites, Ryan S-
dc.contributor.authorChiu, Christopher-
dc.contributor.authorScott, Nichollas E-
dc.contributor.authorMackenzie, Jason M-
dc.contributor.authorBedoui, Sammy-
dc.contributor.authorReading, Patrick C-
dc.contributor.authorLondrigan, Sarah L-
dc.contributor.authorHelbig, Karla J-
dc.contributor.authorRandolph, Adrienne G-
dc.contributor.authorThomas, Paul G-
dc.contributor.authorXu, Jianqing-
dc.contributor.authorWang, Zhongfang-
dc.contributor.authorChua, Brendon Y-
dc.contributor.authorKedzierska, Katherine-
dc.date2024-
dc.date.accessioned2024-09-12T00:53:26Z-
dc.date.available2024-09-12T00:53:26Z-
dc.date.issued2024-08-22-
dc.identifier.citationCell 2024-08-22; 187(17)en_US
dc.identifier.issn1097-4172-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/35478-
dc.description.abstractRespiratory infections cause significant morbidity and mortality, yet it is unclear why some individuals succumb to severe disease. In patients hospitalized with avian A(H7N9) influenza, we investigated early drivers underpinning fatal disease. Transcriptomics strongly linked oleoyl-acyl-carrier-protein (ACP) hydrolase (OLAH), an enzyme mediating fatty acid production, with fatal A(H7N9) early after hospital admission, persisting until death. Recovered patients had low OLAH expression throughout hospitalization. High OLAH levels were also detected in patients hospitalized with life-threatening seasonal influenza, COVID-19, respiratory syncytial virus (RSV), and multisystem inflammatory syndrome in children (MIS-C) but not during mild disease. In olah-/- mice, lethal influenza infection led to survival and mild disease as well as reduced lung viral loads, tissue damage, infection-driven pulmonary cell infiltration, and inflammation. This was underpinned by differential lipid droplet dynamics as well as reduced viral replication and virus-induced inflammation in macrophages. Supplementation of oleic acid, the main product of OLAH, increased influenza replication in macrophages and their inflammatory potential. Our findings define how the expression of OLAH drives life-threatening viral disease.en_US
dc.language.isoeng-
dc.subjectMIS-Cen_US
dc.subjectOLAHen_US
dc.subjectSARS-CoV-2 and RSVen_US
dc.subjectfatal avian A/H7N9 influenza diseaseen_US
dc.subjectinfluenza mouse modelen_US
dc.subjectlife-threatening seasonal influenzaen_US
dc.subjectolah(−/−) miceen_US
dc.subjectolah-driven macrophage-mediated disease severityen_US
dc.subjectoleoyl-ACP hydrolase as key early driver of disease severityen_US
dc.titleHigh expression of oleoyl-ACP hydrolase underpins life-threatening respiratory viral diseases.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleCellen_US
dc.identifier.affiliationDepartment of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.en_US
dc.identifier.affiliationDepartment of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Center for Infectious Diseases Research, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.en_US
dc.identifier.affiliationDepartment of Microbiology, Anatomy, Physiology and Pharmacology, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, VIC 3086, Australia.en_US
dc.identifier.affiliationDepartment of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.en_US
dc.identifier.affiliationShanghai Public Health Clinical Centre and Institutes of Biomedical Sciences, Key Laboratory of Medical Molecular Virology of Ministry of Education/Health, Shanghai Medical College, Fudan University, Shanghai 201508, China.en_US
dc.identifier.affiliationShanghai Public Health Clinical Centre, Fudan University, Shanghai 201508, China.en_US
dc.identifier.affiliationDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.en_US
dc.identifier.affiliationDepartment of Anesthesiology, Critical Care, and Pain Medicine, Boston Children's Hospital and Department of Anaesthesia, Harvard Medical School, Boston, MA 02115, USA.en_US
dc.identifier.affiliationMelbourne Mass Spectrometry and Proteomics Facility, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC 3052, Australia.en_US
dc.identifier.affiliationInfection and Immunity Program, Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.en_US
dc.identifier.affiliationWalter Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia; Olivia Newton-John Cancer Research Institute, Heidelberg, VIC 3084, Australia; School of Cancer Medicine, La Trobe University, Bundoora, VIC 3086, Australia.en_US
dc.identifier.affiliationDepartment of Anatomy and Physiology, University of Melbourne, Parkville, VIC 3010, Australia.en_US
dc.identifier.affiliationDepartment of Anatomy and Comparative Pathology and Toxicology, Pathology and Immunology Group, University of Córdoba, International Excellence Agrifood Campus "CeiA3", 14014 Córdoba, Spain.en_US
dc.identifier.affiliationDepartment of Pediatrics, University of Tennessee Health Science Center, Memphis, TN 38163, USA.en_US
dc.identifier.affiliationDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.en_US
dc.identifier.affiliationDepartment of Molecular, Cell & Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA 95064, USA.en_US
dc.identifier.affiliationDepartment of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.en_US
dc.identifier.affiliationDepartment of Cardiothoracic Surgery, Royal Children's Hospital, University of Melbourne, Melbourne Centre for Cardiovascular Genomics and Regenerative Medicine, Parkville, VIC 3052, Australia.en_US
dc.identifier.affiliationDepartment of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia; Institute of Innovation, Science and Sustainability, Federation University Australia, Ballarat, VIC 3353, Australia.en_US
dc.identifier.affiliationSchool of Health Sciences and School of Medicine, University of Tasmania, Launceston, TAS 7248, Australia; School of Health and Biomedical Science, RMIT University, Bundoora, VIC 3083, Australia; Tasmanian Vaccine Trial Centre, Clifford Craig Foundation, Launceston General Hospital, Launceston, TAS 7250, Australia.en_US
dc.identifier.affiliationOlivia Newton-John Cancer Research Instituteen_US
dc.identifier.affiliationWalter Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia; Olivia Newton-John Cancer Research Institute, Heidelberg, VIC 3084, Australia; School of Cancer Medicine, La Trobe University, Bundoora, VIC 3086, Australia.en_US
dc.identifier.affiliationCenter for Infectious Diseases Research, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.en_US
dc.identifier.affiliationInfection and Immunity Program, Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia; Institute of Infection and Immunity, School of Medicine, Cardiff University, Heath Park, Cardiff, UK.en_US
dc.identifier.affiliationNational Heart and Lung Institute, Imperial College London, London SW7 2AZ, UK.en_US
dc.identifier.affiliationDepartment of Infectious Disease, Imperial College London, London, UK.en_US
dc.identifier.affiliationDepartment of Microbiology, Anatomy, Physiology and Pharmacology, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, VIC 3086, Australia.en_US
dc.identifier.affiliationDepartment of Anesthesiology, Critical Care, and Pain Medicine, Boston Children's Hospital and Department of Anaesthesia, Harvard Medical School, Boston, MA 02115, USA; Center for Influenza Disease and Emergence Response (CIDER), Athens, GA, USA.en_US
dc.identifier.affiliationDepartment of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Center for Infectious Diseases Research, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Center for Influenza Disease and Emergence Response (CIDER), Athens, GA, USA.en_US
dc.identifier.affiliationShanghai Public Health Clinical Centre and Institutes of Biomedical Sciences, Key Laboratory of Medical Molecular Virology of Ministry of Education/Health, Shanghai Medical College, Fudan University, Shanghai 201508, China.en_US
dc.identifier.doi10.1016/j.cell.2024.07.026en_US
dc.type.contentTexten_US
dc.identifier.pubmedid39137778-
dc.description.volume187-
dc.description.issue17-
dc.description.startpage4586-
dc.description.endpage4604.e20-
dc.subject.meshtermssecondaryCOVID-19/virology-
dc.subject.meshtermssecondaryCOVID-19/genetics-
dc.subject.meshtermssecondaryInfluenza, Human/virology-
dc.subject.meshtermssecondaryMacrophages/metabolism-
dc.subject.meshtermssecondaryMacrophages/virology-
dc.subject.meshtermssecondaryLung/virology-
dc.subject.meshtermssecondaryLung/pathology-
dc.subject.meshtermssecondaryLung/metabolism-
dc.subject.meshtermssecondaryOleic Acid/metabolism-
dc.subject.meshtermssecondaryRespiratory Syncytial Virus Infections/virology-
dc.subject.meshtermssecondaryCarboxylic Ester Hydrolases/metabolism-
dc.subject.meshtermssecondaryCarboxylic Ester Hydrolases/genetics-
dc.subject.meshtermssecondaryOrthomyxoviridae Infections/virology-
dc.subject.meshtermssecondaryRespiratory Tract Infections/virology-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeJournal Article-
item.grantfulltextnone-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.languageiso639-1en-
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