Please use this identifier to cite or link to this item:
https://ahro.austin.org.au/austinjspui/handle/1/35452
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Maeda, Akinori | - |
dc.contributor.author | Chaba, Anis | - |
dc.contributor.author | Inokuchi, Ryota | - |
dc.contributor.author | Pandey, Dinesh | - |
dc.contributor.author | Spano, Sofia | - |
dc.contributor.author | Phongphithakchai, Atthaphong | - |
dc.contributor.author | Hikasa, Yukiko | - |
dc.contributor.author | Pattamin, Nuttapol | - |
dc.contributor.author | Eastwood, Glenn M | - |
dc.contributor.author | Jahanabadi, Hossein | - |
dc.contributor.author | Seevanayagam, Siven | - |
dc.contributor.author | Motley, Andrew N | - |
dc.contributor.author | Bellomo, Rinaldo | - |
dc.date | 2024 | - |
dc.date.accessioned | 2024-09-10T01:43:06Z | - |
dc.date.available | 2024-09-10T01:43:06Z | - |
dc.date.issued | 2024-07-10 | - |
dc.identifier.citation | Journal of Cardiothoracic and Vascular Anesthesia 2024-07-10 | en_US |
dc.identifier.issn | 1532-8422 | - |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/35452 | - |
dc.description.abstract | Carboxyhemoglobin (CO-Hb) is a marker of hemolysis and inflammation, both risk factors for cardiac surgery-associated AKI (CSA-AKI). However, the association between CO-Hb and CSA-AKI remains unknown. A retrospective cohort study. Tertiary university-affiliated metropolitan hospital: single center. Adult on-pump cardiac surgery patients from July 2014 to June 2022 (N = 1,698). None. Patients were stratified into quartiles based on CO-Hb levels at intensive care unit (ICU) admission. A progressive increased risk of CSA-AKI was observed with higher CO-Hb levels at ICU admission. On multivariable logistic regression analysis, the highest quartile (CO-Hb ≥ 1.4%) showed an independent association with the occurrence of CSA-AKI (odds ratio 1.45 compared to the lowest quartile [CO-Hb < 1.0%], 95% CI 1.023-2.071; p = 0.038). Compared to patients with CO-Hb <1.4%, patients with CO-Hb ≥ 1.4% at ICU admission had significantly higher postoperative creatinine (135 vs 116 μmol/L, p < 0.001), higher rates of postoperative RRT (6.7% vs 2.3%, p < 0.001) and AKI (p < 0.001) on univariable analysis and shorter time to event for AKI or death (p < 0.001). CO-Hb ≥ 1.4% at ICU admission is an independent risk factor for CSA-AKI, which is easily obtainable and available on routine arterial blood gas measurements. Thus, CO-Hb may serve as a practical and biologically logical biomarker for risk stratification and population enrichment in trials of CSA-AKI prevention. | en_US |
dc.language.iso | eng | - |
dc.subject | acute kidney injury | en_US |
dc.subject | biomarker | en_US |
dc.subject | carboxyhemoglobin | en_US |
dc.subject | cardiac surgery | en_US |
dc.subject | cardiopulmonary bypass | en_US |
dc.title | Carboxyhemoglobin as Potential Biomarker for Cardiac Surgery Associated Acute Kidney Injury. | en_US |
dc.type | Journal Article | en_US |
dc.identifier.journaltitle | Journal of Cardiothoracic and Vascular Anesthesia | en_US |
dc.identifier.affiliation | Intensive Care | en_US |
dc.identifier.affiliation | Department of Emergency and Critical Care Medicine, The University of Tokyo, Tokyo, Japan; Department of Clinical Engineering, The University of Tokyo, Tokyo, Japan. | en_US |
dc.identifier.affiliation | Data Analytics Research and Evaluation (DARE) Centre | en_US |
dc.identifier.affiliation | Clinical Analytics and Reporting | en_US |
dc.identifier.affiliation | Department of Cardiac Surgery, Austin Hospital, Melbourne, VIC, Australia. | en_US |
dc.identifier.affiliation | Department of Haematology and Blood Bank, Austin Hospital, Melbourne, Australia. | en_US |
dc.identifier.affiliation | Department of Intensive Care, Austin Hospital, Melbourne, VIC, Australia; Department of Clinical Engineering, The University of Tokyo, Tokyo, Japan; Department of Critical Care, The University of Melbourne, Melbourne, VIC, Australia; Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, VIC, Australia. | en_US |
dc.identifier.doi | 10.1053/j.jvca.2024.07.016 | en_US |
dc.type.content | Text | en_US |
dc.identifier.pubmedid | 39084930 | - |
item.openairetype | Journal Article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | No Fulltext | - |
crisitem.author.dept | Intensive Care | - |
crisitem.author.dept | Clinical Analytics and Reporting | - |
crisitem.author.dept | Endocrinology | - |
crisitem.author.dept | Quality and Patient Safety | - |
crisitem.author.dept | Intensive Care | - |
crisitem.author.dept | Data Analytics Research and Evaluation (DARE) Centre | - |
Appears in Collections: | Journal articles |
Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.