Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/34957
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dc.contributor.authorKaramesinis, Alexandra D-
dc.contributor.authorSerpa Neto, Ary-
dc.contributor.authorShi, Jenny-
dc.contributor.authorFletcher, Calvin-
dc.contributor.authorHinton, Jake-
dc.contributor.authorXing, Zhongyue-
dc.contributor.authorPenny-Dimri, Jahan C-
dc.contributor.authorRamson, Dhruvesh-
dc.contributor.authorLiu, Zhengyang-
dc.contributor.authorPlummer, Mark-
dc.contributor.authorSmith, Julian A-
dc.contributor.authorSegal, Reny-
dc.contributor.authorBellomo, Rinaldo-
dc.contributor.authorPerry, Luke A-
dc.date2023-
dc.date.accessioned2024-01-30T23:22:52Z-
dc.date.available2024-01-30T23:22:52Z-
dc.date.issued2024-03-
dc.identifier.citationJournal of Cardiothoracic and Vascular Anesthesia 2024-03; 38(3)en_US
dc.identifier.issn1532-8422-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/34957-
dc.description.abstractTo assess whether there are sex-based differences in the administration of opioid analgesic drugs among inpatients after cardiac surgery. A retrospective cohort study. At a tertiary academic referral center. Adult patients who underwent cardiac surgery from 2014 to 2019. None. The primary outcome was the cumulative oral morphine equivalent dose (OMED) for the postoperative admission. Secondary outcomes were the daily difference in OMED and the administration of nonopioid analgesics. The authors developed multivariate regression models controlling for known confounders, including weight and length of stay. A total of 3,822 patients (1,032 women and 2,790 men) were included. The mean cumulative OMED was 139 mg for women and 180 mg for men, and this difference remained significant after adjustment for confounders (adjusted mean difference [aMD], -33.21 mg; 95% CI, -47.05 to -19.36 mg; p < 0.001). The cumulative OMED was significantly lower in female patients on postoperative days 1 to 5, with the greatest disparity observed on day 5 (aMD, -89.83 mg; 95% CI, -155.9 to -23.80 mg; p = 0.009). By contrast, women were more likely to receive a gabapentinoid (odds ratio, 1.91; 95% CI, 1.42-2.58; p < 0.001). The authors found no association between patient sex and the administration of other nonopioid analgesics or specific types of opioid analgesics. The authors found no association between patient sex and pain scores recorded within the first 48 hours after extubation, or the number of opioids administered in close proximity to pain assessments. Female sex was associated with significantly lower amounts of opioids administered after cardiac surgery.en_US
dc.language.isoeng-
dc.subjectcardiac surgeryen_US
dc.subjectnon-opioid analgesiaen_US
dc.subjectopioid analgesiaen_US
dc.subjectpostoperative painen_US
dc.subjectsex differencesen_US
dc.titleSex Differences in Opioid Administration After Cardiac Surgery.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleJournal of Cardiothoracic and Vascular Anesthesiaen_US
dc.identifier.affiliationDepartment of Anaesthesia and Pain Management, Royal Melbourne Hospital, Parkville, Australia.en_US
dc.identifier.affiliationAustralian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia; Department of Critical Care, Melbourne Medical School, University of Melbourne, Austin Hospital, Melbourne, Australia; Department of Intensive Care, Austin Hospital, Melbourne, Australia; Department of Critical Care, Hospital Israelita Albert Einstein, São Paulo, Brazil.en_US
dc.identifier.affiliationDepartment of Anaesthesia and Pain Management, Royal Melbourne Hospital, Parkville, Australia.en_US
dc.identifier.affiliationDepartment of Anaesthesiology and Perioperative Medicine, The Alfred Hospital, Melbourne, Australia.en_US
dc.identifier.affiliationDepartment of Surgery (School of Clinical Sciences at Monash Health), Monash University and Department of Cardiothoracic Surgery, Monash Health, Clayton, Australia.en_US
dc.identifier.affiliationDepartment of Anaesthesia and Pain Management, Royal Melbourne Hospital, Parkville, Australia; Department of Critical Care, Melbourne Medical School, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, Australia.en_US
dc.identifier.affiliationIntensive Careen_US
dc.identifier.doi10.1053/j.jvca.2023.11.044en_US
dc.type.contentTexten_US
dc.identifier.pubmedid38238202-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.grantfulltextnone-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptIntensive Care-
crisitem.author.deptData Analytics Research and Evaluation (DARE) Centre-
crisitem.author.deptIntensive Care-
crisitem.author.deptData Analytics Research and Evaluation (DARE) Centre-
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