Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/34868
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dc.contributor.authorMo, Allison-
dc.contributor.authorWood, Erica-
dc.contributor.authorShortt, Jake-
dc.contributor.authorCharlton, Andrew-
dc.contributor.authorEvers, Dorothea-
dc.contributor.authorHoeks, Marlijn-
dc.contributor.authorPritchard, Elizabeth-
dc.contributor.authorDaly, James-
dc.contributor.authorHodgson, Carol-
dc.contributor.authorOpat, Stephen-
dc.contributor.authorBowen, David-
dc.contributor.authorReynolds, John-
dc.contributor.authorThi Phung Thao, Le-
dc.contributor.authorStanworth, Simon J-
dc.contributor.authorMcQuilten, Zoe-
dc.date2024-
dc.date.accessioned2024-01-19T05:25:03Z-
dc.date.available2024-01-19T05:25:03Z-
dc.date.issued2024-01-12-
dc.identifier.citationTransfusion 2024-01-12en_US
dc.identifier.issn1537-2995-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/34868-
dc.description.abstractAnemia in myelodysplastic syndromes (MDS) is associated with poorer health-related quality of life (HRQoL) and physical function, and is frequently treated with transfusions. The current common practice of transfusing multiple red blood cells (RBC) units every 2-4 weeks may result in peaks/troughs in hemoglobin (Hb) level, yet maintaining a stable Hb may better improve HRQoL. We describe a study protocol aiming to investigate the feasibility of weekly low-dose RBC transfusion in MDS patients, including assessing HRQoL and physical function outcomes. In this n-of-1 pilot study, patients receive two treatment arms, with randomly allocated treatment sequence: arm A (patient's usual transfusion schedule) and arm B (weekly transfusion, individualized per patient). To facilitate timely delivery of weekly transfusion, extended-matched RBCs are provided, with transfusion based upon the previous week's Hb/pre-transfusion testing results to eliminate delays of awaiting contemporaneous cross-matching. Primary outcome is the feasibility of delivering weekly transfusion. Secondary outcomes include HRQoL, functional activity measurements, RBC usage, and alloimmunization rates. A qualitative substudy explores patient and staff experiences. The trial is open in Australia, Netherlands, and UK. The first patient was recruited in 2020. Inter-country differences in providing RBCs are observed, including patient genotyping versus serological phenotyping to select compatible units. This pilot trial evaluates a novel personalized transfusion approach of weekly matched RBC transfusion and challenges the dogma of current routine pre-transfusion matching practice. Findings on study feasibility, HRQoL, and physical functional outcomes and the qualitative substudy will inform the design of a larger definitive trial powered for clinical outcomes.en_US
dc.language.isoeng-
dc.subjectRBC transfusionen_US
dc.subjecttransfusion practices (adult)en_US
dc.subjecttransfusion practices (oncology-hematology)en_US
dc.titleRethinking the transfusion pathway in myelodysplastic syndromes: Study protocol for a novel randomized feasibility n-of-1 trial of weekly-interval red cell transfusion in myelodysplastic syndromes.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleTransfusionen_US
dc.identifier.affiliationTransfusion Research Unit, School of Public Health & Preventive Medicine, Monash University, Australia.;Department of Haematology, Monash Health, Clayton, Australia.;Austin Pathology & Department of Haematology, Austin Health, Heidelberg, Australia.en_US
dc.identifier.affiliationTransfusion Research Unit, School of Public Health & Preventive Medicine, Monash University, Australia.;Department of Haematology, Monash Health, Clayton, Australia.en_US
dc.identifier.affiliationDepartment of Haematology, Monash Health, Clayton, Australia.;Department of Medicine, School of Clinical Sciences, Faculty of Medicine, Nursing & Health Sciences, Monash University, Melbourne, Australia.en_US
dc.identifier.affiliationDepartment of Haematology, The Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle, UK.;Transfusion Medicine, NHS Blood and Transplant, Oxford, UK.en_US
dc.identifier.affiliationPathologyen_US
dc.identifier.affiliationDepartment of Haematology, Radboudumc, Nijmegen, The Netherlands.en_US
dc.identifier.affiliationSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.en_US
dc.identifier.affiliationAustralian Red Cross Lifeblood, Melbourne, Australia.en_US
dc.identifier.affiliationThe Australian and New Zealand Intensive Care-Research Centre, Monash University, Melbourne, Australia.;The Alfred, Melbourne, Australia.;The George Institute for Global Health, Sydney, Australia.;Department of Critical Care, The University of Melbourne, Melbourne, Australia.en_US
dc.identifier.affiliationDepartment of Haematology, Monash Health, Clayton, Australia.en_US
dc.identifier.affiliationDepartment of Health Sciences, University of York, York, UK.en_US
dc.identifier.affiliationDepartment of Clinical Haematology, The Alfred, Melbourne, Australia.;Australian Centre for Blood Diseases, Central Clinical School, Monash University, Melbourne, Australia.en_US
dc.identifier.affiliationLaboratory Haematologyen_US
dc.identifier.affiliationTransfusion Medicine, NHS Blood and Transplant, Oxford, UK.;Department of Haematology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.;Radcliffe Department of Medicine, University of Oxford, Oxford, UK.en_US
dc.identifier.affiliationTransfusion Research Unit, School of Public Health & Preventive Medicine, Monash University, Australia.;Department of Haematology, Monash Health, Clayton, Australia.en_US
dc.identifier.doi10.1111/trf.17706en_US
dc.type.contentTexten_US
dc.identifier.orcid0000-0002-1923-3133en_US
dc.identifier.orcid0000-0001-9661-6835en_US
dc.identifier.orcid0000-0001-9698-7185en_US
dc.identifier.pubmedid38214417-
item.grantfulltextnone-
item.openairetypeJournal Article-
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
crisitem.author.deptClinical Haematology-
crisitem.author.deptPathology-
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