Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/34394
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dc.contributor.authorMochizuki, Katsunori-
dc.contributor.authorFujii, Tomoko-
dc.contributor.authorPaul, Eldho-
dc.contributor.authorAnstey, Matthew-
dc.contributor.authorPilcher, David V-
dc.contributor.authorBellomo, Rinaldo-
dc.date2023-
dc.date.accessioned2023-12-13T05:24:39Z-
dc.date.available2023-12-13T05:24:39Z-
dc.date.issued2021-03-
dc.identifier.citationCritical Care and Resuscitation : Journal of the Australasian Academy of Critical Care Medicine 2021-03; 23(1)en_US
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/34394-
dc.description.abstractObjective: We aimed to measure the incidence, prevalence, characteristics and outcomes of intensive care unit (ICU) patients with early (first 24 hours) metabolic acidosis (MA) according to two different levels of severity with a focus on recent data. Design: We retrospectively applied two diagnostic criteria to our analysis based on literature for early MA: i) severe MA criteria (pH ≤ 7.20 and Paco2 ≤ 45 mmHg and HCO3- ≤ 20 mmol/L with total Sequential Organ Failure Assessment [SOFA] score ≥ 4 or lactate ≥ 2 mmol/L), and ii) moderate MA criteria (pH < 7.30 and base excess < -4 mmol/L and Paco2 ≤ 45 mmHg). Setting: ICUs in the Australian and New Zealand Intensive Care Society Adult Patient Database program. Participants: Adult patients registered to the database from 2008 to 2018. Main outcome measures: Incidence, prevalence, and hospital mortality of patients with MA by the two criteria. Results: We screened 1 076 087 patients. Given the Australian and New Zealand population during the study period, we estimated the incidence of severe MA at 39.5 per million per year versus 349.2-411.5 per million per year for moderate MA. In the most recent 2 years, we observed early severe MA in 1.5% (1350/87 110) of patients compared with 8.4% (20 679/244 740) for moderate MA. Overall, hospital mortality for patients with early severe MA was 48.3% (652/1350) compared with 21.5% (4444/20 679) for moderate MA. Conclusions: Early severe MA is uncommon in Australian and New Zealand ICUs and carries a very high mortality. Moderate MA is over seven-fold more common and still carries a high mortality.en_US
dc.language.isoeng-
dc.titleEarly metabolic acidosis in critically ill patients: a binational multicentre study.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleCritical Care and Resuscitation : Journal of the Australasian Academy of Critical Care Medicineen_US
dc.identifier.affiliationAustralian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, VIC, Australia.;Department of Emergency and Critical Care Medicine, Shinshu University School of Medicine, Matsumoto, Japan.en_US
dc.identifier.affiliationIntensive Care Unit, Jikei University Hospital, Tokyo, Japan.en_US
dc.identifier.affiliationAustralian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, VIC, Australia.en_US
dc.identifier.affiliationIntensive Care, Sir Charles Gairdner Hospital, Perth, WA, Australia.;School of Medicine, University of Western Australia, Perth, WA, Australia.en_US
dc.identifier.affiliationDepartment of Intensive Care, The Alfred, Melbourne, VIC, Australia.;Australian and New Zealand Intensive Care Society Centre for Outcome and Resource Evaluation, Melbourne, VIC, Australia.en_US
dc.identifier.affiliationAustralian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, VIC, Australia.;Department of Intensive Care, Austin Hospital, Melbourne, VIC, Australia.;Department of Intensive Care, Royal Melbourne Hospital, Melbourne, VIC, Australia.;Centre for Integrated Critical Care, Department of Medicine, the University of Melbourne, Melbourne, VIC, Australia.en_US
dc.identifier.affiliationIntensive Careen_US
dc.identifier.doi10.51893/2021.1.OA6en_US
dc.type.contentTexten_US
dc.identifier.pubmedid38046393-
dc.description.volume23-
dc.description.issue1-
dc.description.startpage67-
dc.description.endpage75-
item.openairetypeJournal Article-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.languageiso639-1en-
crisitem.author.deptIntensive Care-
crisitem.author.deptData Analytics Research and Evaluation (DARE) Centre-
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