Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/34384
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dc.contributor.authorDonaldson, Lachlan H-
dc.contributor.authorHammond, Naomi E-
dc.contributor.authorAgarwal, Sidharth-
dc.contributor.authorTaylor, Sean-
dc.contributor.authorBompoint, Severine-
dc.contributor.authorCoombes, Julieann-
dc.contributor.authorBennett-Brook, Keziah-
dc.contributor.authorBellomo, Rinaldo-
dc.contributor.authorMyburgh, John-
dc.contributor.authorVenkatesh, Balasubramanian-
dc.date2023-
dc.date.accessioned2023-12-13T05:24:36Z-
dc.date.available2023-12-13T05:24:36Z-
dc.date.issued2022-03-07-
dc.identifier.citationCritical Care and Resuscitation : Journal of the Australasian Academy of Critical Care Medicine 2022-03-07; 24(1)en_US
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/34384-
dc.description.abstractObjective: To describe the pattern of acute illness and 6-month mortality and health-related quality-of-life outcomes for a cohort of Aboriginal and Torres Strait Islander patients presenting with septic shock. Design: Nested cohort study of Aboriginal and Torres Strait Islander participants recruited to a large randomised controlled trial of corticosteroid treatment in patients with septic shock. Setting: Royal Darwin Hospital, Northern Territory. Participants: All Aboriginal and Torres Strait Islander patients recruited to the Adjunctive Corticosteroid Treatment in Critically Ill Patients with Septic Shock (ADRENAL) trial at Royal Darwin Hospital were compared with a non-Indigenous cohort drawn from the same site, and a cohort matched for age, sex and severity of disease. Main outcome measures: Mortality at 90 days and 6 months, time to shock resolution, mechanical ventilation requirement, renal replacement therapy requirement, and five-domain, five-level EuroQol questionnaire (EQ-5D-5L) score at 6 months. Results: Aboriginal and Torres Strait Islander patients had significantly reduced risk of death at 90 days when compared with non-Indigenous patients recruited to ADRENAL at Royal Darwin Hospital (12/60 v 23/62; adjusted odds ratio, 0.40 [95% CI, 0.17 to 0.94]) which was robust to additional adjustment for baseline covariates (odds ratio, 0.35 [95% CI, 0.14 to 0.90]). When compared with the matched population drawn from the broader ADRENAL cohort, there was no significant difference in 90-day mortality (12/60 v 16/61; adjusted odds ratio, 1.43 [95% CI, 0.60 to 3.39]; P = 0.42). Only nine Aboriginal and Torres Strait Islander patients provided 6-month health-related quality-of-life data. Conclusions: Aboriginal and Torres Strait Islander patients had reduced risk of death at 90 days when compared with non- Indigenous patients recruited to the ADRENAL trial at Royal Darwin Hospital, which was robust to adjustment for covariates, but similar outcomes when compared with a cohort matched for age, sex and severity of disease.en_US
dc.language.isoeng-
dc.titleOutcomes following severe septic shock in a cohort of Aboriginal and Torres Strait Islander people: a nested cohort study from the ADRENAL trial.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleCritical Care and Resuscitation : Journal of the Australasian Academy of Critical Care Medicineen_US
dc.identifier.affiliationThe George Institute for Global Health, Faculty of Medicine, UNSW, Sydney, NSW, Australia.;Malcolm Fisher Department of Intensive Care Medicine, Royal North Shore Hospital, Sydney, NSW, Australia.en_US
dc.identifier.affiliationThe George Institute for Global Health, Faculty of Medicine, UNSW, Sydney, NSW, Australia.;Malcolm Fisher Department of Intensive Care Medicine, Royal North Shore Hospital, Sydney, NSW, Australia.en_US
dc.identifier.affiliationIntensive Care Unit, Royal Darwin Hospital, Casuarina, NT, Australia.en_US
dc.identifier.affiliationMenzies School of Health Research, Charles Darwin University, Darwin, NT, Australia.en_US
dc.identifier.affiliationDepartment of Intensive Care, Royal Melbourne Hospital, Melbourne, VIC, Australia.;Centre for Integrated Critical Care, University of Melbourne, Melbourne, VIC, Australia.;Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, VIC, Australia.en_US
dc.identifier.affiliationData Analytics Research and Evaluation (DARE) Centreen_US
dc.identifier.affiliationThe George Institute for Global Health, Faculty of Medicine, UNSW, Sydney, NSW, Australia.;Princess Alexandra Hospital, Brisbane, QLD, Australia.;The Wesley Hospital, Brisbane, QLD, Australia.;Faculty of Medicine, University of Queensland, Brisbane, QLD, Australia.en_US
dc.identifier.doi10.51893/2022.1.OA3en_US
dc.type.contentTexten_US
dc.identifier.pubmedid38046842-
dc.description.volume24-
dc.description.issue1-
dc.description.startpage20-
dc.description.endpage28-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.grantfulltextnone-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptIntensive Care-
crisitem.author.deptData Analytics Research and Evaluation (DARE) Centre-
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