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https://ahro.austin.org.au/austinjspui/handle/1/34384
Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Donaldson, Lachlan H | - |
dc.contributor.author | Hammond, Naomi E | - |
dc.contributor.author | Agarwal, Sidharth | - |
dc.contributor.author | Taylor, Sean | - |
dc.contributor.author | Bompoint, Severine | - |
dc.contributor.author | Coombes, Julieann | - |
dc.contributor.author | Bennett-Brook, Keziah | - |
dc.contributor.author | Bellomo, Rinaldo | - |
dc.contributor.author | Myburgh, John | - |
dc.contributor.author | Venkatesh, Balasubramanian | - |
dc.date | 2023 | - |
dc.date.accessioned | 2023-12-13T05:24:36Z | - |
dc.date.available | 2023-12-13T05:24:36Z | - |
dc.date.issued | 2022-03-07 | - |
dc.identifier.citation | Critical Care and Resuscitation : Journal of the Australasian Academy of Critical Care Medicine 2022-03-07; 24(1) | en_US |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/34384 | - |
dc.description.abstract | Objective: To describe the pattern of acute illness and 6-month mortality and health-related quality-of-life outcomes for a cohort of Aboriginal and Torres Strait Islander patients presenting with septic shock. Design: Nested cohort study of Aboriginal and Torres Strait Islander participants recruited to a large randomised controlled trial of corticosteroid treatment in patients with septic shock. Setting: Royal Darwin Hospital, Northern Territory. Participants: All Aboriginal and Torres Strait Islander patients recruited to the Adjunctive Corticosteroid Treatment in Critically Ill Patients with Septic Shock (ADRENAL) trial at Royal Darwin Hospital were compared with a non-Indigenous cohort drawn from the same site, and a cohort matched for age, sex and severity of disease. Main outcome measures: Mortality at 90 days and 6 months, time to shock resolution, mechanical ventilation requirement, renal replacement therapy requirement, and five-domain, five-level EuroQol questionnaire (EQ-5D-5L) score at 6 months. Results: Aboriginal and Torres Strait Islander patients had significantly reduced risk of death at 90 days when compared with non-Indigenous patients recruited to ADRENAL at Royal Darwin Hospital (12/60 v 23/62; adjusted odds ratio, 0.40 [95% CI, 0.17 to 0.94]) which was robust to additional adjustment for baseline covariates (odds ratio, 0.35 [95% CI, 0.14 to 0.90]). When compared with the matched population drawn from the broader ADRENAL cohort, there was no significant difference in 90-day mortality (12/60 v 16/61; adjusted odds ratio, 1.43 [95% CI, 0.60 to 3.39]; P = 0.42). Only nine Aboriginal and Torres Strait Islander patients provided 6-month health-related quality-of-life data. Conclusions: Aboriginal and Torres Strait Islander patients had reduced risk of death at 90 days when compared with non- Indigenous patients recruited to the ADRENAL trial at Royal Darwin Hospital, which was robust to adjustment for covariates, but similar outcomes when compared with a cohort matched for age, sex and severity of disease. | en_US |
dc.language.iso | eng | - |
dc.title | Outcomes following severe septic shock in a cohort of Aboriginal and Torres Strait Islander people: a nested cohort study from the ADRENAL trial. | en_US |
dc.type | Journal Article | en_US |
dc.identifier.journaltitle | Critical Care and Resuscitation : Journal of the Australasian Academy of Critical Care Medicine | en_US |
dc.identifier.affiliation | The George Institute for Global Health, Faculty of Medicine, UNSW, Sydney, NSW, Australia.;Malcolm Fisher Department of Intensive Care Medicine, Royal North Shore Hospital, Sydney, NSW, Australia. | en_US |
dc.identifier.affiliation | The George Institute for Global Health, Faculty of Medicine, UNSW, Sydney, NSW, Australia.;Malcolm Fisher Department of Intensive Care Medicine, Royal North Shore Hospital, Sydney, NSW, Australia. | en_US |
dc.identifier.affiliation | Intensive Care Unit, Royal Darwin Hospital, Casuarina, NT, Australia. | en_US |
dc.identifier.affiliation | Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia. | en_US |
dc.identifier.affiliation | Department of Intensive Care, Royal Melbourne Hospital, Melbourne, VIC, Australia.;Centre for Integrated Critical Care, University of Melbourne, Melbourne, VIC, Australia.;Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, VIC, Australia. | en_US |
dc.identifier.affiliation | Data Analytics Research and Evaluation (DARE) Centre | en_US |
dc.identifier.affiliation | The George Institute for Global Health, Faculty of Medicine, UNSW, Sydney, NSW, Australia.;Princess Alexandra Hospital, Brisbane, QLD, Australia.;The Wesley Hospital, Brisbane, QLD, Australia.;Faculty of Medicine, University of Queensland, Brisbane, QLD, Australia. | en_US |
dc.identifier.doi | 10.51893/2022.1.OA3 | en_US |
dc.type.content | Text | en_US |
dc.identifier.pubmedid | 38046842 | - |
dc.description.volume | 24 | - |
dc.description.issue | 1 | - |
dc.description.startpage | 20 | - |
dc.description.endpage | 28 | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
item.openairetype | Journal Article | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.dept | Intensive Care | - |
crisitem.author.dept | Data Analytics Research and Evaluation (DARE) Centre | - |
Appears in Collections: | Journal articles |
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