Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/33955
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dc.contributor.authorCui, Jing-
dc.contributor.authorLin, Wenmin-
dc.contributor.authorMay, Brian H-
dc.contributor.authorLuo, Qiulan-
dc.contributor.authorWorsnop, Christopher J-
dc.contributor.authorZhang, Anthony Lin-
dc.contributor.authorGuo, Xinfeng-
dc.contributor.authorLu, Chuanjian-
dc.contributor.authorLi, Yunying-
dc.contributor.authorXue, Charlie C-
dc.date2023-
dc.date.accessioned2023-10-11T06:21:18Z-
dc.date.available2023-10-11T06:21:18Z-
dc.date.issued2023-
dc.identifier.citationPloS One 2023; 18(10)en_US
dc.identifier.issn1932-6203-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/33955-
dc.description.abstractThis systematic review and meta-analysis aims to: assess the effectiveness and safety of orally administered Chinese herbal medicines (CHMs) as adjuncts to the post-surgical management of chronic rhinosinusitis (CRS); inform clinicians of the current evidence; identify the best available evidence; and suggest directions for further research. Randomised controlled trials (RCTs) were identified from searches of nine databases plus clinical trial registries. Participants were adults and/or children diagnosed with sinusitis or rhinosinusitis, with or without nasal polyps, who had received surgery. Interventions were CHMs used orally following surgery for CRS as additions to conventional post-surgical management. Controls received conventional post-surgical management without CHMs. Studies reported results for Sino-Nasal Outcome Test (SNOT), visual analogue scales (VAS), Lund-Mackay computed tomography score (LM), Lund-Kennedy endoscopic score (LK), mucociliary transport time (MTT), mucociliary transport rate (MTR), mucociliary clearance (MC) or quality of life (QoL). Twenty-one RCTs were included. All used oral CHMs following functional endoscopic sinus surgery (FESS). The pooled results showed no significant difference between groups for SNOT-20 at the end of treatment (EoT) but there was a significant difference at follow up (FU) in favour of additional CHMs. The VAS for total nasal symptoms (VAS-TNS) showed greater improvements in the CHM groups at EoT and FU. Only FU data were reported for LM which showed greater improvement in the CHM groups. LK showed greater improvements at EoT and FU. The measures of mucociliary transport (MTT, MTR, and MC) each showed significantly greater improvement at EoT in the group that received additional CHMs. No study reported QoL. Adverse events were not serious, but reporting was incomplete. The meta-analyses suggested the addition of oral CHMs to conventional management following FESS may improve recovery. However, most studies were not blinded, and substantial heterogeneity was evident in some meta-analyses. Blinded studies are required to further investigate the roles of oral CHMs in post-surgical recovery. Systematic review registration number: The protocol was registered in PROSPERO (CRD42019119586).en_US
dc.language.isoeng-
dc.titleOrally administered Chinese herbal therapy to assist post-surgical recovery for chronic rhinosinusitis-A systematic review and meta-analysis.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitlePloS Oneen_US
dc.identifier.affiliationChina-Australia International Research Centre for Chinese Medicine, School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, Australia.en_US
dc.identifier.affiliationThe Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, and The Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou, China.;Otorhinolaryngology Head and Neck Department, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China.en_US
dc.identifier.affiliationChina-Australia International Research Centre for Chinese Medicine, School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, Australia.en_US
dc.identifier.affiliationThe Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, and The Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou, China.;Otorhinolaryngology Head and Neck Department, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China.en_US
dc.identifier.affiliationRespiratory and Sleep Medicineen_US
dc.identifier.affiliationChina-Australia International Research Centre for Chinese Medicine, School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, Australia.en_US
dc.identifier.affiliationThe Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, and The Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou, China.en_US
dc.identifier.affiliationChina-Australia International Research Centre for Chinese Medicine, School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, Australia.;The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, and The Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou, China.en_US
dc.identifier.doi10.1371/journal.pone.0292138en_US
dc.type.contentTexten_US
dc.identifier.orcid0000-0001-6531-0702en_US
dc.identifier.orcid0000-0001-6937-9088en_US
dc.identifier.pubmedid37797052-
dc.description.volume18-
dc.description.issue10-
dc.description.startpagee0292138-
item.openairetypeJournal Article-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptRespiratory and Sleep Medicine-
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