Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/33812
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dc.contributor.authorAitken, Blair-
dc.contributor.authorHayley, Amie C-
dc.contributor.authorFord, Talitha C-
dc.contributor.authorGeier, Lauren-
dc.contributor.authorShiferaw, Brook A-
dc.contributor.authorDowney, Luke A-
dc.date2023-
dc.date.accessioned2023-09-27T05:36:42Z-
dc.date.available2023-09-27T05:36:42Z-
dc.date.issued2023-12-
dc.identifier.citationJournal of Psychopharmacology (Oxford, England) 2023-12; 37(12)en_US
dc.identifier.issn1461-7285-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/33812-
dc.description.abstractRecreational co-consumption of benzodiazepines and alcohol is a common practise; yet, the cognitive effects of this combination remain poorly understood. This study aimed to investigate the acute cognitive effects of combining a 1 mg dose of alprazolam with a moderate dose of alcohol (target 0.04% blood alcohol concentration (BAC)) in a non-clinical population. In this randomised, double-blind, placebo-controlled, crossover trial, participants completed computerised cognitive assessments and the brief biphasic alcohol effects scale (B-BAES) after consuming 1 mg of alprazolam, both with and without a moderate dose of alcohol (target 0.04% BAC). Among 20 healthy participants (mean age = 28.6, SD ± 4.0 years, 60% female), we found that a peak BAC of 0.03% had no significant impact on cognitive performance. Both the individual use of alprazolam and its combination with alcohol resulted in impaired reaction time, digit vigilance, and verbal, spatial and numeric working memory tasks, although an additive effect when alcohol and alprazolam were consumed together was not evident. The most pronounced cognitive effects occurred at 100 min after dosing, coinciding with increased alprazolam concentrations. Sedative effects were heightened with alcohol, alprazolam and their combination while no stimulative effects were reported. Our findings highlight the significant implications of a therapeutic dose of alprazolam on impairing cognitive performance. This is particularly relevant considering the frequency of non-medical alprazolam use. Future studies should explore different dosages, administration timings and long-term effects to inform the development of public health policies and guidelines regarding the combined use of alcohol and benzodiazepines.en_US
dc.language.isoeng-
dc.subjectAlprazolamen_US
dc.subjectalcoholen_US
dc.subjectbenzodiazepinesen_US
dc.subjectcognitive performanceen_US
dc.subjectrandomised controlled trialen_US
dc.titleAcute administration of alprazolam, alcohol and their combination on cognitive performance and mood: A randomised, double-blind, placebo-controlled study.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleJournal of Psychopharmacology (Oxford, England)en_US
dc.identifier.affiliationCentre for Mental Health and Brain Sciences, Swinburne University of Technology, Hawthorn, VIC, Australia.en_US
dc.identifier.affiliationInstitute for Breathing and Sleepen_US
dc.identifier.affiliationCognitive Neuroscience Unit, Deakin University, Geelong, VIC, Australia.en_US
dc.identifier.affiliationForensic Science SA, Adelaide, SA, Australia.en_US
dc.identifier.affiliationSeeing Machines Ltd., Fyshwick, ACT, Australia.en_US
dc.identifier.doi10.1177/02698811231200878en_US
dc.type.contentTexten_US
dc.identifier.orcid0000-0001-7607-7344en_US
dc.identifier.orcid0000-0002-4470-4718en_US
dc.identifier.pubmedid37724443-
dc.description.startpage2698811231200878-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.grantfulltextnone-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptInstitute for Breathing and Sleep-
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