Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/33746
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dc.contributor.authorAllebone, James-
dc.contributor.authorKanaan, Richard A A-
dc.contributor.authorRayner, Genevieve-
dc.contributor.authorMaller, Jerome-
dc.contributor.authorO'Brien, Terence J-
dc.contributor.authorMullen, Saul A-
dc.contributor.authorCook, Mark-
dc.contributor.authorAdams, Sophia J-
dc.contributor.authorVogrin, Simon-
dc.contributor.authorVaughan, David N-
dc.contributor.authorKwan, Patrick-
dc.contributor.authorBerkovic, Samuel F-
dc.contributor.authorD'Souza, Wendyl J-
dc.contributor.authorJackson, Graeme D-
dc.contributor.authorVelakoulis, Dennis-
dc.contributor.authorWilson, Sarah J-
dc.date2023-
dc.date.accessioned2023-09-20T07:00:04Z-
dc.date.available2023-09-20T07:00:04Z-
dc.date.issued2023-09-15-
dc.identifier.citationEpilepsy Research 2023-09-15; 196en_US
dc.identifier.issn1872-6844-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/33746-
dc.description.abstractThe neuropsychological profile of patients with psychosis of epilepsy (POE) has received limited research attention. Recent neuroimaging work in POE has identified structural network pathology in the default mode network and the cognitive control network. This study examined the neuropsychological profile of POE focusing on cognitive domains subserved by these networks. Twelve consecutive patients with a diagnosis of POE were prospectively recruited from the Comprehensive Epilepsy Programmes at The Royal Melbourne, Austin and St Vincent's Hospitals, Melbourne, Australia between January 2015 and February 2017. They were compared to 12 matched patients with epilepsy but no psychosis and 42 healthy controls on standardised neuropsychological tests of memory and executive functioning in a case-control design. Mean scores across all cognitive tasks showed a graded pattern of impairment, with the POE group showing the poorest performance, followed by the epilepsy without psychosis and the healthy control groups. This was associated with significant group-level differences on measures of working memory (p = < 0.01); immediate (p = < 0.01) and delayed verbal recall (p = < 0.01); visual memory (p < 0.001); and verbal fluency (p = 0.02). In particular, patients with POE performed significantly worse than the healthy control group on measures of both cognitive control (p = .005) and memory (p < .001), whereas the epilepsy without psychosis group showed only memory difficulties (delayed verbal recall) compared to healthy controls (p = .001). People with POE show reduced performance in neuropsychological functions supported by the default mode and cognitive control networks, when compared to both healthy participants and people with epilepsy without psychosis.en_US
dc.language.isoeng-
dc.subjectInterictal psychosisen_US
dc.subjectMemory, epilepsyen_US
dc.subjectPostictal psychosisen_US
dc.subjectPsychosisen_US
dc.titleNeuropsychological function in psychosis of epilepsy.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleEpilepsy Researchen_US
dc.identifier.affiliationClinical Neuropsychologyen_US
dc.identifier.affiliationPsychiatry (University of Melbourne)en_US
dc.identifier.affiliationMelbourne School of Psychological Sciences, University of Melbourne, Victoria, Australia; The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia; Comprehensive Epilepsy Program, Austin Health, University of Melbourne, Victoria, Australia; Department of Clinical Neuropsychology, Austin Health, Heidelberg, Victoria, Australia.en_US
dc.identifier.affiliationANU College of Health and Medicine, Australian National University, Canberra, Victoria, Australia; Monash Alfred Psychiatry Research Centre, The Alfred and Monash University, Melbourne, Australia; Department of Clinical Neuropsychology, Austin Health, Heidelberg, Victoria, Australia.en_US
dc.identifier.affiliationRoyal Melbourne Hospital, Melbourne, Victoria, Australia; Department of Neuroscience, Alfred Hospital, Monash University, Melbourne, Australia; Department of Clinical Neuropsychology, Austin Health, Heidelberg, Victoria, Australia.en_US
dc.identifier.affiliationThe Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia.en_US
dc.identifier.affiliationGraeme Clark Institute, University of Melbourne, Melbourne, Australia; Department of Clinical Neuropsychology, Austin Health, Heidelberg, Victoria, Australia.en_US
dc.identifier.affiliationRoyal Melbourne Hospital, Melbourne, Victoria, Australia; Department of Clinical Neuropsychology, Austin Health, Heidelberg, Victoria, Australia.en_US
dc.identifier.affiliationSt Vincent's Hospital, Melbourne, Victoria, Australia; Department of Clinical Neuropsychology, Austin Health, Heidelberg, Victoria, Australia.en_US
dc.identifier.affiliationComprehensive Epilepsy Programen_US
dc.identifier.affiliationRoyal Melbourne Hospital, Melbourne, Victoria, Australia; Department of Neuroscience, Alfred Hospital, Monash University, Melbourne, Australia.en_US
dc.identifier.affiliationDepartment of Medicine, St Vincent's Hospital, The University of Melbourne, Australia; Department of Clinical Neuropsychology, Austin Health, Heidelberg, Victoria, Australia.en_US
dc.identifier.affiliationNeuropsychiatry Unit, Royal Melbourne Hospital, Melbourne, Victoria, Australia; Melbourne Neuropsychiatry Centre, University of Melbourne and Melbourne, Health, Melbourne, Australia; Department of Clinical Neuropsychology, Austin Health, Heidelberg, Victoria, Australia.en_US
dc.identifier.affiliationMelbourne School of Psychological Sciences, University of Melbourne, Victoria, Australia; The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia.en_US
dc.identifier.doi10.1016/j.eplepsyres.2023.107222en_US
dc.type.contentTexten_US
dc.identifier.pubmedid37717505-
dc.description.volume196-
dc.description.startpage107222-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.openairetypeJournal Article-
item.languageiso639-1en-
item.fulltextNo Fulltext-
crisitem.author.deptPsychiatry (University of Melbourne)-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
crisitem.author.deptEpilepsy Research Centre-
crisitem.author.deptEpilepsy Research Centre-
crisitem.author.deptNeurology-
crisitem.author.deptNeurology-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
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