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https://ahro.austin.org.au/austinjspui/handle/1/33570
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DC Field | Value | Language |
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dc.contributor.author | El-Habashy, Dina M | - |
dc.contributor.author | Wahid, Kareem A. | - |
dc.contributor.author | He, Renjie | - |
dc.contributor.author | McDonald, Brigid | - |
dc.contributor.author | Rigert, Jillian | - |
dc.contributor.author | Ng, Sweet Ping | - |
dc.date | 2023 | - |
dc.date.accessioned | 2023-08-23T07:20:05Z | - |
dc.date.available | 2023-08-23T07:20:05Z | - |
dc.date.issued | 2023-09 | - |
dc.identifier.citation | Clinical and Translational Radiation Oncology 2023-09; 42 | en_US |
dc.identifier.issn | 2405-6308 | - |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/33570 | - |
dc.description.abstract | We aim to characterize the serial quantitative apparent diffusion coefficient (ADC) changes of the target disease volume using diffusion-weighted imaging (DWI) acquired weekly during radiation therapy (RT) on a 1.5 T MR-Linac and correlate these changes with tumor response and oncologic outcomes for head and neck squamous cell carcinoma (HNSCC) patients as part of a programmatic R-IDEAL biomarker characterization effort. Thirty patients with HNSCC who received curative-intent RT at MD Anderson Cancer Center, were included. Baseline and weekly MRI were obtained, and various ADC parameters were extracted from the regions of interest (ROIs). Baseline and weekly ADC parameters were correlated with response during and after RT, and the recurrence using the Mann-Whitney U test. The Wilcoxon signed-rank test was used to compare the weekly ADC versus baseline values. Weekly volumetric changes (Δvolume) for each ROI were correlated with ΔADC using Spearman's Rho test. Recursive partitioning analysis (RPA) identified the optimal ΔADC threshold associated with different oncologic outcomes. There was a significant rise in all ADC parameters at different time points of RT compared to baseline for both gross primary disease (GTV-P) and gross nodal disease volumes (GTV-N). The increased ADC values for GTV-P were statistically significant only for primary tumors achieving complete remission (CR) during RT. RPA identified GTV-P ΔADC 5th percentile > 13% at the mid-RT as the most significant parameter associated with primary tumors' CR during RT (p < 0.001). There was a significant decrease in residual volume of both GTV-P & GTV-N throughout the course of RT. A significant negative correlation between mean ΔADC and Δvolume for GTV-P at the 3rd and 4th week of RT was detected (r = -0.39, p = 0.044 & r = -0.45, p = 0.019, respectively). Assessment of ADC kinetics at regular intervals throughout RT seems to be correlated with RT response. Further studies with larger cohorts and multi-institutional data are needed for validation of ΔADC as a model for prediction of response to RT. | en_US |
dc.language.iso | eng | - |
dc.subject | ADC | en_US |
dc.subject | DWI | en_US |
dc.subject | Diffusion | en_US |
dc.subject | Head and neck cancer | en_US |
dc.subject | MR-Linac | en_US |
dc.subject | Oncologic outcomes | en_US |
dc.title | Longitudinal diffusion and volumetric kinetics of head and neck cancer magnetic resonance on a 1.5 T MR-linear accelerator hybrid system: A prospective R-IDEAL stage 2a imaging biomarker characterization/pre-qualification study. | en_US |
dc.type | Journal Article | en_US |
dc.identifier.journaltitle | Clinical and Translational Radiation Oncology | en_US |
dc.identifier.affiliation | Radiation Oncology | en_US |
dc.identifier.affiliation | Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA | en_US |
dc.identifier.affiliation | Department of Clinical Oncology and Nuclear Medicine, Menoufia University, Shebin Elkom, Egypt | en_US |
dc.identifier.affiliation | Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA | en_US |
dc.identifier.affiliation | Department of Radiology, Radiation Oncology and Nuclear Medicine, Université de Montréal, Canada | en_US |
dc.identifier.affiliation | University of Houston College of Pharmacy, Houston, TX, USA | en_US |
dc.identifier.affiliation | Department of Radiation Therapy, University Medical Center Utrecht, Utrecht, The Netherlands | en_US |
dc.identifier.affiliation | Department of Head and Neck Surgery, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA | en_US |
dc.identifier.affiliation | Department of Molecular and Cellular Oncology, Division of Basic Science Research, The University of Texas MD Anderson Cancer Center, Houston, TX, USA | en_US |
dc.identifier.affiliation | Philips Healthcare MR Oncology, Cleveland, OH, USA | en_US |
dc.identifier.affiliation | Elekta AB, Stockholm, Sweden | en_US |
dc.identifier.affiliation | Department of Radiation Oncology, Baylor College of Medicine, Houston, TX, USA | en_US |
dc.identifier.doi | 10.1016/j.ctro.2023.100666 | en_US |
dc.type.content | Text | en_US |
dc.identifier.pubmedid | 37583808 | - |
dc.description.volume | 42 | - |
dc.description.startpage | 100666 | - |
item.languageiso639-1 | en | - |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.openairetype | Journal Article | - |
crisitem.author.dept | Radiation Oncology | - |
crisitem.author.dept | Olivia Newton-John Cancer Wellness and Research Centre | - |
Appears in Collections: | Journal articles |
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