Lim, Kenneth Jc

Wellard, Cameron

Talaulikar, Dipti

Tan, Joanne Lc

Loh, Joanna

Puvanakumar, Pratheepan

Kuzich, James A

Ho, Michelle

Murphy, Matthew

Zeglinas, Nicole

Low, Michael Sy

Routledge, David

Lim, Andrew Boon Ming

Gibbs, Simon D

Quach, Hang

Morgan, Sue

Moore, Elizabeth

Ninkovic, Slavisa

2023-08

The prognostic impact of t(11;14) in multiple myeloma (MM) needs to be better understood to inform future treatment decisions. The Australian Lymphoma Leukaemia Group embarked on a retrospective, observational cohort study using real-world data to interrogate treatment patterns and outcomes in 74 MM patients with t(11;14) [t(11;14)-MM] diagnosed over 10 years. This was compared to 159 and 111 MM patients with high-risk IgH translocations (IgH HR-MM) and hyperdiploidy (Hyperdiploid-MM), respectively, from the Australian Myeloma and Related Diseases Registry. No appreciable differences in age, gender, ISS, LDH levels, 1q21 or del(17p) status, or treatment patterns were observed between groups. Median PFS-1 was not different between groups but both t(11;14)-MM and IgH HR-MM had an inferior PFS-2 vs. Hyperdiploid-MM: median PFS-2 8.2 months, 10.0 months, and 19.8 months (p = 0.002), respectively. The 3-year OS were 69%, 71%, and 82% (p = 0.026), respectively. In the t(11;14)-MM group, gain or amplification of 1q21 at diagnosis predicted for poorer OS (HR 3.46, p = 0.002). Eleven patients had received venetoclax with 45% achieving better than a very good partial response. Results suggest that t(11;14) MM may confer an unfavorable risk profile and that the use of targeted therapies such as venetoclax earlier in the treatment algorithm should be explored.

EJHaem 2023-08; 4(3)

2688-6146

EJHaem

0000-0002-2664-116X

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0000-0001-6766-8345

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0000-0002-3657-8010

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0000-0002-3881-6000

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https://ahro.austin.org.au/austinjspui/handle/1/33557

BCL2

multiple myeloma

t(11;14)

venetoclax

The prognostic impact of t(11;14) in multiple myeloma: A real-world analysis from the Australian Lymphoma Leukaemia Group (ALLG) and the Australian Myeloma and Related Diseases Registry (MRDR).

Journal Article