Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/33441
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dc.contributor.authorZarbock, Alexander-
dc.contributor.authorWeiss, Raphael-
dc.contributor.authorAlbert, Felix-
dc.contributor.authorRutledge, Kristen-
dc.contributor.authorKellum, John A-
dc.contributor.authorBellomo, Rinaldo-
dc.contributor.authorGrigoryev, Evgeny-
dc.contributor.authorCandela-Toha, Angel M-
dc.contributor.authorDemir, Z Aslı-
dc.contributor.authorLegros, Vincent-
dc.contributor.authorRosenberger, Peter-
dc.contributor.authorGalán Menéndez, Patricia-
dc.contributor.authorGarcia Alvarez, Mercedes-
dc.contributor.authorPeng, Ke-
dc.contributor.authorLéger, Maxime-
dc.contributor.authorKhalel, Wegdan-
dc.contributor.authorOrhan-Sungur, Mukadder-
dc.contributor.authorMeersch, Melanie-
dc.date2023-
dc.date.accessioned2023-08-03T00:23:16Z-
dc.date.available2023-08-03T00:23:16Z-
dc.date.issued2023-12-
dc.identifier.citationIntensive Care Medicine 2023-12; 49(12)en_US
dc.identifier.issn1432-1238-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/33441-
dc.description.abstractThe incidence, patient features, risk factors and outcomes of surgery-associated postoperative acute kidney injury (PO-AKI) across different countries and health care systems is unclear. We conducted an international prospective, observational, multi-center study in 30 countries in patients undergoing major surgery (> 2-h duration and postoperative intensive care unit (ICU) or high dependency unit admission). The primary endpoint was the occurrence of PO-AKI within 72 h of surgery defined by the Kidney Disease: Improving Global Outcomes (KDIGO) criteria. Secondary endpoints included PO-AKI severity and duration, use of renal replacement therapy (RRT), mortality, and ICU and hospital length of stay. We studied 10,568 patients and 1945 (18.4%) developed PO-AKI (1236 (63.5%) KDIGO stage 1500 (25.7%) KDIGO stage 2209 (10.7%) KDIGO stage 3). In 33.8% PO-AKI was persistent, and 170/1945 (8.7%) of patients with PO-AKI received RRT in the ICU. Patients with PO-AKI had greater ICU (6.3% vs. 0.7%) and hospital (8.6% vs. 1.4%) mortality, and longer ICU (median 2 (Q1-Q3, 1-3) days vs. 3 (Q1-Q3, 1-6) days) and hospital length of stay (median 14 (Q1-Q3, 9-24) days vs. 10 (Q1-Q3, 7-17) days). Risk factors for PO-AKI included older age, comorbidities (hypertension, diabetes, chronic kidney disease), type, duration and urgency of surgery as well as intraoperative vasopressors, and aminoglycosides administration. In a comprehensive multinational study, approximately one in five patients develop PO-AKI after major surgery. Increasing severity of PO-AKI is associated with a progressive increase in adverse outcomes. Our findings indicate that PO-AKI represents a significant burden for health care worldwide.en_US
dc.language.isoeng-
dc.subjectAcute kidney injuryen_US
dc.subjectEpidemiologyen_US
dc.subjectMortalityen_US
dc.subjectPerioperativeen_US
dc.subjectPostoperativeen_US
dc.titleEpidemiology of surgery associated acute kidney injury (EPIS-AKI): a prospective international observational multi-center clinical study.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleIntensive Care Medicineen_US
dc.identifier.affiliationDepartment of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Albert-Schweitzer-Campus 1, Gebäude A1, 48149, Münster, Germany.;Outcome Research Consortium, Cleveland, OH, USA.en_US
dc.identifier.affiliationDepartment of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Albert-Schweitzer-Campus 1, Gebäude A1, 48149, Münster, Germany.en_US
dc.identifier.affiliationInstitute of Biostatistics and Clinical Research, University of Münster, Münster, Germany.en_US
dc.identifier.affiliationDepartment of Anesthesiology and Perioperative Medicine, University of Alabama, Birmingham, USA.en_US
dc.identifier.affiliationCenter for Critical Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA.en_US
dc.identifier.affiliationDepartment of Critical Care, The University of Melbourne, Melbourne, Australia.en_US
dc.identifier.affiliationDepartment of Anesthesiology, Kemerovo Cardiology Centre, Kemerovo, Russia.en_US
dc.identifier.affiliationDepartment of Anesthesiology, University Hospital Ramón y Cajal, Madrid, Spain.en_US
dc.identifier.affiliationDepartment of Anesthesiology, Ankara Bilkent City Hospital, Health Science University, Ankara, Turkey.en_US
dc.identifier.affiliationDepartment of Anesthesiology and Critical Care, Hôpital Maison Blanche, University Hospital, 51100, Reims, France.en_US
dc.identifier.affiliationDepartment of Anesthesiology and Intensive Care, University Hospital Tübingen, Tübingen, Germany.en_US
dc.identifier.affiliationDepartment of Anesthesiology and Intensive Care, University Hospital Vall d'Hebron, Barcelona, Spain.en_US
dc.identifier.affiliationDepartment of Anesthesiology, Hospital de Sant Pau, University of Barcelona, Barcelona, Spain.en_US
dc.identifier.affiliationDepartment of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, China.en_US
dc.identifier.affiliationDepartment of Anesthesiology and Intensive Care, Centre Hospitalier Universitaire d'Angers, Angers, France.en_US
dc.identifier.affiliationDepartment of Anesthesiology, Tripoli Central Hospital, Tripoli, Libya.en_US
dc.identifier.affiliationDepartment of Anesthesiology and Reanimation, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey.en_US
dc.identifier.affiliationDepartment of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Albert-Schweitzer-Campus 1, Gebäude A1, 48149, Münster, Germany.en_US
dc.identifier.affiliationDepartment of Intensive Care, Royal Melbourne Hospital, Parkville, VIC, Australia.en_US
dc.identifier.affiliationIntensive Careen_US
dc.identifier.affiliationAustralian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.en_US
dc.identifier.doi10.1007/s00134-023-07169-7en_US
dc.type.contentTexten_US
dc.identifier.orcid0000-0002-2124-1714en_US
dc.identifier.pubmedid37505258-
item.openairetypeJournal Article-
item.cerifentitytypePublications-
item.fulltextWith Fulltext-
item.grantfulltextopen-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptIntensive Care-
crisitem.author.deptData Analytics Research and Evaluation (DARE) Centre-
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