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https://ahro.austin.org.au/austinjspui/handle/1/33382
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Mo, Allison | - |
dc.contributor.author | Poynton, Matthew | - |
dc.contributor.author | Wood, Erica | - |
dc.contributor.author | Shortt, Jake | - |
dc.contributor.author | Brunskill, Susan J | - |
dc.contributor.author | Doree, Carolyn | - |
dc.contributor.author | Sandercock, Josie | - |
dc.contributor.author | Saadah, Nicholas | - |
dc.contributor.author | Luk, Edwin | - |
dc.contributor.author | Stanworth, Simon J | - |
dc.contributor.author | McQuilten, Zoe | - |
dc.date | 2023 | - |
dc.date.accessioned | 2023-07-26T06:36:57Z | - |
dc.date.available | 2023-07-26T06:36:57Z | - |
dc.date.issued | 2023-09 | - |
dc.identifier.citation | Blood Reviews 2023-09; 61 | en_US |
dc.identifier.issn | 1532-1681 | - |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/33382 | - |
dc.description.abstract | Anemia is common in Myelodysplastic Syndromes (MDS). Different anemia treatments have been tested in clinical studies, but the full impact on patients' health-related quality of life (HRQoL) and physical function is unknown. The main aim of this review was to assess whether improvements in anemia are associated with changes in HRQoL/physical function. Twenty-six full-text publications were identified, enrolling 2211 patients: nine randomized trials (RCTs), fourteen non-randomized studies of interventions and three cross-sectional studies. Interventions included: growth factors/erythropoiesis-stimulating agents (n = 14), red cell transfusion (n = 9), erythroid maturation agents (n = 1), or a combination (n = 2). Five RCTs reported no changes in HRQoL despite erythroid response to the intervention, raising the question of whether anemia treatment alone can effectively improve HRQoL. Many studies were considered at high risk of bias for assessing HRQoL. There is a pressing need for future clinical trials to better define the nature of the relationship between anemia and HRQoL/functional outcomes. | en_US |
dc.language.iso | eng | - |
dc.subject | Anemia | en_US |
dc.subject | Myelodysplastic syndrome | en_US |
dc.subject | Physical function | en_US |
dc.subject | Quality of life | en_US |
dc.subject | Transfusion medicine | en_US |
dc.title | Do anemia treatments improve quality of life and physical function in patients with myelodysplastic syndromes (MDS)? A systematic review. | en_US |
dc.type | Journal Article | en_US |
dc.identifier.journaltitle | Blood Reviews | en_US |
dc.identifier.affiliation | Transfusion Research Unit, School of Public Health & Preventive Medicine, Monash University, Australia; Department of Haematology, Monash Health, Clayton, Australia | en_US |
dc.identifier.affiliation | Department of Haematology, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom. | en_US |
dc.identifier.affiliation | Transfusion Research Unit, School of Public Health & Preventive Medicine, Monash University, Australia; Department of Haematology, Monash Health, Clayton, Australia. | en_US |
dc.identifier.affiliation | Department of Haematology, Monash Health, Clayton, Australia; School of Clinical Sciences, Monash University, Australia. | en_US |
dc.identifier.affiliation | Pathology | en_US |
dc.identifier.affiliation | Laboratory Haematology | en_US |
dc.identifier.affiliation | Systematic Review Initiative, NHS Blood and Transplant, Oxford, United Kingdom. | en_US |
dc.identifier.affiliation | Transfusion Research Unit, School of Public Health & Preventive Medicine, Monash University, Australia. | en_US |
dc.identifier.affiliation | Department of Medicine (Royal Melbourne Hospital), University of Melbourne, Melbourne, Australia. | en_US |
dc.identifier.affiliation | Department of Haematology, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom; NHS Blood and Transplant, John Radcliffe Hospital, Oxford, United Kingdom; Radcliffe Department of Medicine, University of Oxford, United Kingdom. | en_US |
dc.identifier.affiliation | Transfusion Research Unit, School of Public Health & Preventive Medicine, Monash University, Australia; Department of Haematology, Monash Health, Clayton, Australia. | en_US |
dc.identifier.doi | 10.1016/j.blre.2023.101114 | en_US |
dc.type.content | Text | en_US |
dc.identifier.pubmedid | 37479599 | - |
dc.description.startpage | 101114 | - |
local.name.researcher | Mo, Allison | - |
item.openairetype | Journal Article | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.languageiso639-1 | en | - |
crisitem.author.dept | Clinical Haematology | - |
crisitem.author.dept | Pathology | - |
Appears in Collections: | Journal articles |
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