Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/33382
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dc.contributor.authorMo, Allison-
dc.contributor.authorPoynton, Matthew-
dc.contributor.authorWood, Erica-
dc.contributor.authorShortt, Jake-
dc.contributor.authorBrunskill, Susan J-
dc.contributor.authorDoree, Carolyn-
dc.contributor.authorSandercock, Josie-
dc.contributor.authorSaadah, Nicholas-
dc.contributor.authorLuk, Edwin-
dc.contributor.authorStanworth, Simon J-
dc.contributor.authorMcQuilten, Zoe-
dc.date2023-
dc.date.accessioned2023-07-26T06:36:57Z-
dc.date.available2023-07-26T06:36:57Z-
dc.date.issued2023-09-
dc.identifier.citationBlood Reviews 2023-09; 61en_US
dc.identifier.issn1532-1681-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/33382-
dc.description.abstractAnemia is common in Myelodysplastic Syndromes (MDS). Different anemia treatments have been tested in clinical studies, but the full impact on patients' health-related quality of life (HRQoL) and physical function is unknown. The main aim of this review was to assess whether improvements in anemia are associated with changes in HRQoL/physical function. Twenty-six full-text publications were identified, enrolling 2211 patients: nine randomized trials (RCTs), fourteen non-randomized studies of interventions and three cross-sectional studies. Interventions included: growth factors/erythropoiesis-stimulating agents (n = 14), red cell transfusion (n = 9), erythroid maturation agents (n = 1), or a combination (n = 2). Five RCTs reported no changes in HRQoL despite erythroid response to the intervention, raising the question of whether anemia treatment alone can effectively improve HRQoL. Many studies were considered at high risk of bias for assessing HRQoL. There is a pressing need for future clinical trials to better define the nature of the relationship between anemia and HRQoL/functional outcomes.en_US
dc.language.isoeng-
dc.subjectAnemiaen_US
dc.subjectMyelodysplastic syndromeen_US
dc.subjectPhysical functionen_US
dc.subjectQuality of lifeen_US
dc.subjectTransfusion medicineen_US
dc.titleDo anemia treatments improve quality of life and physical function in patients with myelodysplastic syndromes (MDS)? A systematic review.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleBlood Reviewsen_US
dc.identifier.affiliationTransfusion Research Unit, School of Public Health & Preventive Medicine, Monash University, Australia; Department of Haematology, Monash Health, Clayton, Australiaen_US
dc.identifier.affiliationDepartment of Haematology, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom.en_US
dc.identifier.affiliationTransfusion Research Unit, School of Public Health & Preventive Medicine, Monash University, Australia; Department of Haematology, Monash Health, Clayton, Australia.en_US
dc.identifier.affiliationDepartment of Haematology, Monash Health, Clayton, Australia; School of Clinical Sciences, Monash University, Australia.en_US
dc.identifier.affiliationPathologyen_US
dc.identifier.affiliationLaboratory Haematologyen_US
dc.identifier.affiliationSystematic Review Initiative, NHS Blood and Transplant, Oxford, United Kingdom.en_US
dc.identifier.affiliationTransfusion Research Unit, School of Public Health & Preventive Medicine, Monash University, Australia.en_US
dc.identifier.affiliationDepartment of Medicine (Royal Melbourne Hospital), University of Melbourne, Melbourne, Australia.en_US
dc.identifier.affiliationDepartment of Haematology, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom; NHS Blood and Transplant, John Radcliffe Hospital, Oxford, United Kingdom; Radcliffe Department of Medicine, University of Oxford, United Kingdom.en_US
dc.identifier.affiliationTransfusion Research Unit, School of Public Health & Preventive Medicine, Monash University, Australia; Department of Haematology, Monash Health, Clayton, Australia.en_US
dc.identifier.doi10.1016/j.blre.2023.101114en_US
dc.type.contentTexten_US
dc.identifier.pubmedid37479599-
dc.description.startpage101114-
local.name.researcherMo, Allison-
item.openairetypeJournal Article-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.languageiso639-1en-
crisitem.author.deptClinical Haematology-
crisitem.author.deptPathology-
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